Laboratory for Metabolomics

List

2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
1995-2002


2021

  1. Aoyagi R, Yamamoto T, Furukawa Y, *Arita M. Characterization of the structural diversity and structure-specific behavior of oxidized phospholipids by LC-MS/MS. Chem Pharm Bull 69, 953-961 (2021)
  2. Tokuhiro T, Ishizawa A, Sato H, Takita S, Yoshikawa A, Anzai R, Sato S, Aoyagi R, Arita M, Aratani Y, Shimizu S, Tanaka M, *Yotsumoto S. Oxidized phospholipids and neutrophil elastase coordinately play critical roles in NET formation. Front Cell Dev Biol 9, 718586 (2021)
  3. Kuwashima Y, *Yanagawa M, Abe M, Hiroshima M, Ueda M, Arita M, *Sako Y. Comparative analysis of single-molecule dynamics of TRPV1 and TRPV4 channels in living cells. Int J Mol Biol 22, 8473 (2021)
  4. Kong WS, Tsuyama N, Inoue H, Guo Y, Mokuda S, Nobukiyo A, Nakatani N, Yamaide F, Nakano T, Kohno Y, Ikeda K, Nakanishi Y, Ohno H, Arita M, Shimojo N, *Kanno M. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s. Sci Rep 11, 13109 (2021)
  5. Kikuchi K, Tatebe T, Sudo Y, Yokoyama M, Kidana K, Chiu Y, Takatori S, Arita M, Hori Y, *Tomita T. GPR120 signaling controls amyloid-b degrading activity of matrix metalloproteinases. J Neurosci 41, 6173-6185 (2021)
  6. Miyata J, Yokokura Y, Moro K, Arai H, Fukunaga K, *Arita M. 12/15-Lipoxygenase regulates IL-33-induced eosinophilic airway inflammation in mice. Front Immunol 12, 687192 (2021)
  7. Osada H, Toda E, Homma K, Guzman NA, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, *Ozawa Y. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss. Cell Death Dis 12, 458 (2021)
  8. Ito Y, Sasaki T, Li Y, Tanoue T, Sugiura Y, Skelly AN, Suda W, Kawashima Y, Okahashi N, Watanabe E, Horikawa H, Shiohama A, Kurokawa R, Kawakami E, Iseki H, Kawasaki H, Iwakura Y, Shiota A, Yu L, Hisatsune J, Koseki H, Sugai M, Arita M, Ohara O, Matsui T, Suematsu M, Hattori M, Atarashi K, Amagai M, *Honda K. Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation. Cell Rep 35, 109052 (2021)
  9. Okahashi N, Ueda M, Yasuda S, Tsugawa H, *Arita M. Global profiling of gut microbiota-associated lipid metabolites in antibiotic-treated mice by LC-MS/MS-based analyses. STAR Protoc. 2, 100492 (2021)
  10. *Okahashi N, Ueda M, Matsuda F, *Arita M.Analysis of lipid A in gram-negative intestinal bacteria using liquid chromatography-quadrupole time-of-flight mass spectrometry. Metabolites 11, 197 (2021)
  11. Nishimura T, Oyama T, Hu HT, Fujioka T, Hanawa-Suetsugu K, Ikeda K, Yamada S, Kawana H, Saigusa D, Ikeda H, Kurata R, Oono-Yakura K, Kitamata M, Kida K, Hikita T, Mizutani K, Yasuhara K, Mimori-Kiyosue Y, Oneyama C, Kurimoto K, Hosokawa Y, Aoki J, Takai Y, Arita M, *Suetsugu S.Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells. Dev Cell 56, 842-859 (2021)
  12. Saika A, Nagatake T, Hirata S, Sawane K, Adachi J, Abe Y, Isoyama J, Morimoto S, Node E, Tiwari P, Hosomi K, Matsunaga A, Honda T, Tomonaga T, Arita M, Kabashima K, *Kunisawa J.ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB J 35, e21354 (2021)
  13. *Mi-ichi F, Ikeda K, Tsugawa H, Deoler S, Yoshida H, *Arita M.Stage-specific de novo synthesis of very long chain dihydroceramides confers dormancy in Entamoeba parasites. mSphere 6, e00174-21 (2021)
  14. Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K, Ando F, Susa K, Mandai S, Mori T, Rai T, Uchida S, *Arita M, *Sohara E.Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney. Clin Exp Nephrol 25, 445-455 (2021)
  15. Hirata T, Yamamoto K, Ikeda K, *Arita M. Functional lipidomics of vascular endothelial cells in response to laminar shear stress. FASEB J 35, e21301 (2021)
  16. Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarinov P, Stocker BL, Timmer M, Smith D, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, *Yamasaki S.Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors. J Exp Med 218, e20200815 (2021)
  17. Johmura Y, Yamanaka T, Omori S, Wang T, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama K, Furukawa Y, Imoto S, *Nakanishi M.Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. Science 371, 265-270 (2021)
  18. Nakashima Y, *Sakai Y, Mizuno Y, Furuno K, Hirono K, Takatsuki S, Suzuki H, Onouchi Y, Kobayashi T, Tanabe K, Hamase K, Miyamoto T, Aoyagi R, Arita M, Yamamura K, Tanaka T, Nishio H, Takada H, Ohga S, *Hara T. Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease. Cardiovasc Res 117, 96-108 (2021)
  19. Ogawa K, Asano K, Yotsumoto S, Yamane T, Arita M, Hayashi Y, Harada H, Makino-Okamura C, Fukuyama H, Kondo K, Yamasoba T, *Tanaka M. Frontline Science: Conversion of neutrophils into atypical Ly6G+SiglecF+ immune cells with neurosupportive potential in olfactory neuroepithelium. J Leukoc Biol 109, 481-496 (2021)

>> List


2020

  1. *Sakayori N, Katakura M, Hamazaki K, Higuchi O, Fujii K, Fukabori R, Iguchi Y, Setogawa S, Takao K, Miyazawa T, Arita M, Kobayashi K. Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice. Commun Biol 3, 473 (2020)
  2. Ogawa M, Ishihara T, Isobe Y, Kato T, Kuba K, Imai Y, Uchino Y, Tsubota K, *Arita M. Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway. FASEB J 34, 12492-12501 (2020)
  3. Sanjo H, Yao T, Katagiri K, Sato T, Matsumura T, Komeya M, Yamanaka H, Yao M, Matsuhisa A, Asayama Y, Ikeda K, Kano K, Aoki J, Arita M, *Ogawa T. Antioxidant vitamins and lysophospholipids are critical in inducing mouse spermatogenesis under organ culture condition. FASEB J 34, 9480-9497 (2020)
  4. *Tsugawa H, Ikeda K, Takahashi M, Satoh A, Mori Y, Uchino H, Okahashi N, Yamada Y, Tada I, Bonini P, Higashi Y, Okazaki Y, Zhou Z, Zhu Z, Koelmel J, Cajka T, Fiehn O, Saito K, Arita M, *Arita M. A lipidome atlas in MS-DIAL 4. Nat Biotechnol 38, 1159-1163 (2020)
  5. Morita M, Saito S, Shinohara R, Aoyagi R, Arita M, *Kobayashi Y. Synthesis of phosphatidylcholines possessing functionalized acids at sn-2, and 13C-14N and 13C-31P couplings in their 13C NMR spectra. Synlett 31, 718-722 (2020)
  6. *Sasaki H, Kaneda Y, Rogi T, Shibata H, Aoyagi R, Yamane T, Ikeda K, Arita M. Aging alters lipid mediator biosynthesis from polyunsaturated fatty acids in the brain of senescence-accelerated mice with age-related cognitive dysfunction. Medical Mass Spectrometry 4, 65-75 (2020)
  7. *Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, *Hase K. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice. Science 367, eaaw8429 (2020)
  8. Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Ikeda K, Aoyagi R, Adachi J, Abe Y, Isoyama J, Suzuki H, Tomonaga T, Kiyono H, Kabashima K, Arita M, *Kunisawa J. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy 75, 1935-1951 (2020)
  9. Utsunomiya A, Chino T, Utsunomiya N, Luong VH, Tokuriki A, Naganuma T, Arita M, Higashi K, Saito K, Suzuki N, Ohara A, Sugai M, Sugawara K, Tsuruta D, Oyama N, *Hasegawa M. Homeostatic function of dermokine in the skin barrier and inflammation. J Invest Dermatol 140, 838-849 (2020)
  10. Miyata J, *Fukunaga K, Kawashima Y, Ohara O, Arita M. Cysteinyl leukotriene metabolism of human eosinophils in allergic disease. Allergol Int 69, 28-34 (2020)
  11. *Miyata J, Fukunaga K, Kawashima Y, Ohara O, Kawana A, Asano K, Arita M. . Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergy diseases. Prostaglandins Other Lipid Mediat 150, 106477 (2020)
  12. Kokaji T, Hatano A, Ito Y, Yugi K, Eto M, Morita K, Ohno S, Fujii M, Hironaka K, Egami R, Terakawa A, Tsuchiya T, Ozaki H, Inoue H, Uda S, Kubota H, Suzuki Y, Ikeda K, Arita M, Matsumoto M, Nakayama K, Hirayama A, Soga T, *Kuroda S. Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity. Sci Signal 13, eaaz1236 (2020)
  13. Yasuda S, Okahashi N, Tsugawa H, Ogata Y, Ikeda K, Suda W, Arai H, Hattori M, *Arita M. Elucidation of gut microbiota-associated lipids using LC-MS/MS and 16S rRNA sequence analyses. iScience 23, 101841 (2020)

>> List


2019

  1. Sawane K, Nagatake T, Hosomi K, Hirata S, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Fukumitsu S, Aida K, Tomonaga T, Arita M, *Kunisawa J. Dietary omega-3 fatty acid ameliorates allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice. Nutrients 11, 2868 (2019)
  2. Naoe S, *Tsugawa H, Takahashi M, Ikeda K, *Arita M. Characterization of lipid profiles after dietary intake of polyunsaturated fatty acids using integrated untargeted and targeted lipidomics. Metabolites 9, 241 (2019)
  3. Shishikura K, Kuroha S, Matsueda S, Iseki H, Matsui T, Inoue A, *Arita M. Acyl-CoA synthetase 6 regulates long chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice. FASEB J 33, 14194-14203 (2019)
  4. Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, *Kimura I. Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. Nat Commun 10, 4007 (2019)
  5. Sato T, Horikawa M, Takei S, Yamazaki F, Ito TK, Kondo T, Sakurai T, Kahyo T, Ikegami K, Sato S, Sato R, Jinno Y, Kawano H, Naoe S, Arita M, Kashiwagi Y, *Setou M. Preferential incorporation of administered eicosapentaenoic acid into thin-cap atherosclerotic plaques. Arterioscler Thromb Vasc Biol 39, 1802-1816 (2019)
  6. Liebisch G, Ahrends R, Arita M, Arita M, Bowden JA, Ejsing CS, Griffiths WJ, Holcapek M, Kofeler H, Mitchell TW, Wenk MR, Ekroos K. (Lipidomics Standards Initiative Consortium). 2019. Lipidomics needs more standardization. Nat Metab 1, 745-747 (2019)
  7. Watanabe Y, *Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, *Takatsu K. Bi-directional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB J 33, 11821-11835
  8. *Tsugawa H, Satoh A, Uchino H, Cajka T, Arita M, *Arita M. Mass spectrometry data repository enhances novel metabolite discoveries with advances in computational metabolomics. Metabolites 9, E119 (2019)
  9. Miyata J, Fukunaga K, Kawashima Y, Watanabe T, Saitoh A, Hirosaki T, Araki Y, Kikawada T, Betsuyaku T, Ohara O, *Arita M. Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis. Allergy 74, 1113-1124 (2019)
  10. *Imanishi T, Unno M, Kobayashi W, Yoneda N, Matsuda S, Ikeda K, Hoshi T, Hirao A, Miyake K, Barber GN, Arita M, Ishii KJ, Akira S, *Saito T. Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function. Life Sci Alliance 2, e201800282 (2019)
  11. Kawashima Y, Miyata J, Watanabe T, Shioya J, Arita M, *Ohara O. Proteogenomic analyses of cellular lysates using a phenol-guanidium thiocyanate reagent. J Proteome Res 18, 301-308 (2019)
  12. Yamamoto T, *Miyata J, Arita M, Fukunaga K, Kawana A. Current state and future prospect of therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma. Respir Invest 57, 534-543 (2019)
  13. Ishihara T, Yoshida M, *Arita M. Omega-3 fatty acid–derived mediators that control inflammation and tissue homeostasis. Int Immunol 31, 559-567 (2019)

>> List


2018

  1. Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, *Hattori M. Reelin deficiency leads to aberrant lipid composition in mouse brain. Biochem Biophys Res Commun 505, 81-86 (2018)
  2. Li J, Chen CY, Arita M, Kim K, Li X, Zhang H, *Kang JX. An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis. Carcinogenesis 39, 1380-1388(2018)
  3. Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Oresic M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, *Wenk MR. MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. J Lipid Res 59, 2001-2017 (2018)
  4. Ueharaguchi Y, *Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainichi T, Egawa G, Nakashima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi Y, Kabashima K. Thromboxane A2 facilitates IL-17A production from Vg4+ gdT cells and promotes psoriatic dermatitis in mice. J Allergy Clin Immunol 142, 680-683 (2018)
  5. Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, *Kunisawa J. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol 142, 470-484 (2018)
  6. Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, *Yamazaki K. A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling. Sci Rep 8, 9008 (2018)
  7. Gowda SG, Ikeda K, *Arita M. Facile determination of sphingolipids under alkali condition using metal-free column by LC-MS/MS. Anal Bioanal Chem 410, 4793-4803 (2018)
  8. *Isobe Y, Itagaki M, Ito Y, Naoe S, Kojima K, Ikeguchi M, *Arita M.Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid. Sci Rep 8, 7954 (2018)
  9. Hata M, *Ikeda H, Iwai S, Iida Y, Gotoh N, Asaka I, Ikeda K, Isobe Y, Hori A, Nakagawa S, Yamato S, Arita M, Yoshimura N, Tsujikawa A.Reduction of lipid accumulation rescues Bietti’s crystalline dystrophy phenotypes. Proc Natl Acad Sci USA 115, 3936-3941 (2018)
  10. *Isobe Y, Kawashima Y, Ishihara T, Watanabe K, Ohara O, *Arita M.Identification of protein targets of 12/15-lipoxygenase-derived lipid electrophiles in mouse peritoneal macrophages using omega-alkynyl fatty acid. ACS Chem Biol 13, 887-893 (2018)
  11. Nosaka T, *Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida Y.Alveolar macrophages drive hepatocellular carcinoma lung metastasis by generating leukotriene B4. J Immunol 200, 1839-1852 (2018)
  12. Mochimaru T, *Fukunaga K, Miyata J, Matsusaka M, Masaki K, Kabata H, Ueda S, Suzuki Y, Goto T, Urabe D, Inoue M, Isobe Y, Arita M, Betsuyaku T. 12-OH-17,18-epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs. Allergy 73, 369-378 (2018)
  13. Codagnone M, Cianci E, Lamolinara A, Cecilia Mari V, Nespoli A, Arita M, Bragonzi A, Iezzi M, Romano M, *Recchiuti A. Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection. Mucosal Immunol 11, 35-49 (2018)
  14. Nishimura K, Sakaguchi T, Nanba Y, Suganuma Y, Morita M, Hong S, Lu Y, Jun B, Bazan NG, Arita M, *Kobayashi Y. Stereoselective total synthesis of macrophage-produced prohealing 14,21-dihydroxydocosahexaenoic acids. J Org Chem 83, 154-166 (2018)

>> List


2017

  1. Tsugawa H, Ikeda K, *Arita M. The importance of bioinformatics for connecting data-driven lipidomics and biological insights. Biochim Biophys Acta 1862, 762-765 (2017)
  2. *Ikutani M, Tsuneyama K, Kawaguchi K, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, *Takatsu K. Prolonged activation of IL-5 producing ILC2 causes pulmonary arterial hypertrophy. JCI Insight 2, e90721 (2017)
  3. Tsugawa H, Ikeda K, Tanaka W, Senoo Y, *Arita M, *Arita M. Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library. J Cheminform 9, 19 (2017)
  4. Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, *Ohtani N. Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity. Cancer Discov 7, 522-538 (2017)
  5. Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR,Ikeda K, Arita M, Akiyama M, *Murakami M. PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. Nature Commun 8, 14609 (2017)
  6. Aoyagi R, Ikeda K, Isobe Y, *Arita M. Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library. J Lipid Res 58, 2229-2237 (2017)
  7. Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt BF, *Murakami M, *Arai H. Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation. Nat Med 23, 1287-1297 (2017)
  8. Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, Dodo K, Terayama N, Sodeoka M, Aoyagi R, Arita M, Arakawa S, Shimizu S, *Tanaka M. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep 7, 16026 (2017)
  9. *Takahashi H, Shida D, Tagawa K, Iwamoto R, Arita M, Arai H, Suzuki T. Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial. BMC Surg 17, 90 (2017)
  10. 5. Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, Hirota Y, Fujii T, Tsuchiya S, Taketomi Y, Sugimoto Y, Murakami M, Arita M, Kurano M, Ikeda H, Yatomi Y, Chun J, *Aoki J. Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. EMBO J 36, 2146-2160 (2017)

>> List


2016

  1. Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, *Yanagita M. Heterogenous fibroblasts underlie age-dependent tertially lymphoid tissues in the kidney. JCI Insight 1, e87680 (2016)
  2. *Arita M. Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy. Allergol Int 65, S2-S5 (2016)
  3. Endo J, *Arita M. Cardioprotective mechanism of omega-3 polyunsaturated fatty acids. J Cardiol 67, 22-27 (2016)
  4. Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, *Osumi N. Maternal dietary balance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites. Stem Cells 34, 470-482 (2016)

>> List


2015

  1. Katakura M, *Hashimoto M, Inoue T, Mamun AA, Tanabe Y, Arita M, Shido O. Chronic arachidonic acid administration decreases docosahexaenoic acid and eicosapentaenoic acid-derived metabolites in kidneys of aged rats. PLoS One 10, e0140884 (2015)
  2. Sawada Y, *Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, *Kabashima K. Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. J Exp Med 212, 1921-1930 (2015)
  3. *Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M. Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: a potential alternative to immunosuppression. Intern Med 54, 2377-2382 (2015)
  4. Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, *Ueda K. Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells. J Lipid Res 56, 1880-1890 (2015)
  5. Goto T, Urabe D, Masuda K, Isobe Y, Arita M, *Inoue M. Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities. J Org Chem 80, 7713-7726 (2015)
  6. Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, *Furuta GT. Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis. Gut 64, 1236-1247 (2015)
  7. Nishiokada A, Miyoshi M, Fujiwara M, Aoyama-Ishikawa M, Maeshige M, Takahashi M, Hamada Y, Usami Y, Honda M, Arita M, *Usami M. Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 week in endotoxemic rats using LC-ESI-MS/MS. Clin Nutr 34, 685-693 (2015)
  8. *Kunisawa J, *Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep 5, 9750 (2015)
  9. Miyamoto J, Mizukure T, Park S, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, *Tanabe S. A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40/MEK-ERK pathway. J Biol Chem 290, 2902-2918 (2015)
  10. *Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Inoue T, Hossain S, Arita M, Shido O. n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats. Biochim Biophys Acta 1851, 203-209 (2015)
  11. *Miyata J, Arita M. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergol Int 64, 27-34 (2015)
  12. *Tsugawa H, Cajka T, Kind T, Ma Y, Higgins B, Ikeda K, Kanazawa M, VanderGheynst J, Fiehn O, Arita M. MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. Nat Methods Jun;12(6):523-6(2015)

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2014

  1. Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, *Arita M. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. J Exp Med 211, 1673-1687 (2014)
  2. Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, *Arita M. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J 28, 4036-4043 (2014)
  3. Yokokura Y, Isobe Y, Matsueda S, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H, *Arita M. Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite. J Biochem 156, 315-321 (2014)
  4. Kubota T, *Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H. Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid. FASEB J 28, 586-593 (2014)
  5. Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Lener D, Stanzl U, Seifert M, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Li X, Pallweber P, Scharnagl H, Stojakovic T, Marz W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, *Tancevski I. The arachidonic acid metabolome as conserved regulator of cholesterol metabolism. Cell Metab 20, 787-798 (2014)
  6. *Hirahashi J, Kawahata K, Arita M, Iwamoto R, Hishikawa K, Honda M, Hamasaki Y, Tanaka M, Okubo K, Kurosawa M, Takase O, Nakakuki M, Saiga K, Suzuki K, Kawachi S, Tojo A, Seki G, Marumo T, Hayashi M, Fujita T. Immunomodulation with eicosapentaenoic acid supports the treatment of autoimmune small-vessel vasculitis. Sci Rep 4, 6406 (2014)
  7. Iwaki S, Hokamura K, Ogawa M, Takehara Y, Muramatsu Y, Yamane T, Hirabayashi K, Morimoto Y, Hagisawa K, Nakahara K, Mineno T, Terai T, Komatsu T, Ueno T, Tamura K, Adachi Y, Hirata Y, Arita M, Arai H, Umemura K, Nagano T, *Hanaoka K. A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques. Org Biomol Chem 12, 8611-8618 (2014)
  8. Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, *Furuta GT. Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis. Gut in press
  9. Nishiokada A, Miyoshi M, Fujiwara M, Aoyama-Ishikawa M, Maeshige M, Takahashi M, Hamada Y, Usami Y, Honda M, Arita M, *Usami M. Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 week in endotoxemic rats using LC-ESI-MS/MS. Clin Nutr in press
  10. Onuma H, *Komatsu T, Arita M, Hanaoka K, Ueno T, Terai T, Nagano T, *Inoue T. Rapidly rendering cells phagocytic through a cell-surface display technique and concurrent Rac activation. Sci Signal 7, rs4 (2014)
  11. *Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. J Immunol 193, 1666-1671 (2014)
  12. Nakashima C, *Otsuka A, Kitoh A, Honda T, Egawa G, Nakajima S, Nakamizo S, Arita M, Kubo M, Miyachi Y, *Kabashima K. Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis. J Allergy Clin Immunol 134, 100-107 (2014)
  13. Taguchi A, *Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, kang JX, Arai H, *Arita M, Osuga Y, Fujii T. Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyusaturated fatty acids in vitro and in vivo. PLoS One 27, e89605 (2014)
  14. Katakura M, *Hashimoto M, Inoue T, Al Mamun A, Tanabe Y, Iwamoto R, Arita M, Tsuchikura S, Shido O. Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model. Molecules 19, 3247-3263 (2014)
  15. Ueda T, *Fukunaga K, Seki H, Miyata J, Arita M, Miyasho T, Obata T, Asano K, Betsuyaku T, Takeda J. Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis. Crit Care Med 42, e288-295 (2014)
  16. Isobe Y, *Arita M. Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach. J Clin Biochem Nutr 55, 79-94 (2014)

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2013

  1. Isobe Y, *Arita M, Iwamoto R, Urabe D, Todoroki H, Masuda K, Inoue M, Arai H. Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3. J Biochem 153, 355-360 (2013)
  2. Miyata J, Fukunaga K, Iwamoto R, Isobe Y, Niimi K, Takamiya R, Takihara T, Tomomatsu K, Suzuki Y, Oguma T, Sayama K, Arai H, Betsuyaku T, Arita M, *Asano K. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. J Allergy Clin Immunol 131, 353-360 (2013)
  3. Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanabe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, *Imai Y. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell 153, 112-125 (2013)
  4. Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, *Murakami M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol 14, 554-563 (2013)
  5. Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, *Murakami M. Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. J Exp Med 210, 1217-1234 (2013)
  6. Kishino S, Takeuchi M, Park S, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, *Ogawa J. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci USA 110, 17808-17813 (2013)
  7. Yamashita A, *Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Arai H, *Arita M, Kozuma S, Fujii T. Increased tissue level of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. Sci Rep 3, 3113 (2013)
  8. Tomio K, *Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, *Arita M, Kozuma S, Fujii T. Omega-3 polyunsaturated fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models. PLoS One 8, e73085 (2013)
  9. Fujieda Y, Manno A, Hayashi Y, Rhodes N, Guo L, Arita M, Bamba T, *Fukusaki E. Inflammation and resolution are associated with upregulation of fatty acid beta-oxidation in zymosan-induced peritonitis. PLoS One 8, e66270 (2013)
  10. *Maekawa K, Hirayama A, Iwata Y, Tajima Y, Nishimaki-Mogami T, Sugawara S, Ueno N, Abe H, Ishikawa M, Murayama M, Matsuzawa Y, Nakanishi H, Ikeda K, Arita M, Taguchi R, Minamino N, Wakabayashi S, Soga T, Saito Y. Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. J Mol Cell Cardiol 59, 76-85 (2013)
  11. Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, *Saito Y. Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease. Lipids Health Dis 12, 68 (2013)
  12. Juman S, *Hashimoto M, Katakura M, Inoue T, Tanabe Y, Arita M, Miki T, Shido O. Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. Nutrients 5, 1949-1961 (2013)

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2012

  1. Isobe Y, *Arita M, Matsueda S, Iwamoto R, Fujihara T, Nakanishi H, Taguchi R, Masuda K, Sasaki K, Urabe D, Inoue M, Arai H. Identification and structure determination of novel anti-inflammatory mediator resolvin E3: 17,18-dihydroxyeicosapentaenoic acid. J Biol Chem 287, 10525-10534 (2012)
  2. Lee HC, Inoue T, Sasaki J, Kubo T, Matsuda S, Nakasaki Y, Hattori M, Tanaka F, Udagawa O, Kono N, Itoh T, Ogiso H, Taguchi R, Arita M, Sasaki T, *Arai H. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol Biol Cell 23, 4689-4700 (2012)
  3. *Takamiya R, Fukunaga K, Arita M, Miyata J, Seki H, Minematsu N, Suematsu M, Asano K. Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress. FEBS Open Bio 2, 328-333 (2012)
  4. *Arita M. Mediator lipidomics in acute inflammation and resolution. J Biochem (Invited review) 152, 313-319 (2012)
  5. Isobe Y, Kato T, *Arita M. Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation. Front Immunol 3, 270 (2012)
  6. *Arita M, Iwamoto R, Isobe Y. Mediator lipidomics in inflammation research. Lipidomics, Technologies and Applications. (Ekroos, K. ed.), pp.219-230, Willey-VCH, Weinheim.(2012)

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2011

  1. Yamada T, Tani Y, Nakanishi H, Taguchi R, *Arita M, Arai H. Eosinophils promote resolution of acute peritonitis by producing pro-resolving mediators in mice. FASEB J 25 561-568 (2011)
  2. Sasaki K, Urabe D, Arai H, Arita M, *Inoue M. Total synthesis and bioactivities of two proposed structures of maresin. Chem Asian J 6, 534-543 (2011)

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2010

  1. White PJ, Arita M, Taguchi R, Kang JX, *Marette A. Transgenic restoration of long chain omega-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high fat-fed mice. Diabetes 59, 3066-3073 (2010)
  2. Seki H, Fukunaga K, Arita M, Arai H, Nakanishi H, Taguchi R, Miyasho T, Takamiya R, Asano K, Ishizaka A, Takeda J, *Levy BD. The anti-inflammatory and pro-resolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. J Immunol 184, 836-843 (2010)
  3. Ohira T, Arita M, Omori K, Recchiuti A, Van Dyke TE, *Serhan CN. Resolvin E1 receptor activation signals phosphorylation and phagocytosis. J Biol Chem 285, 3451-3461 (2010)
  4. Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Winkler JW, Petasis NA, Serhan CN, *Bazan NG. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids 82, 27-34 (2010)
  5. Kure I, Nishiumi S, Nishitani Y, Tanoue T, Ishida T, Mizuno M, Fujita T, Kusumi H, Arita M, Azuma T, *Yoshida M. Lipoxin A4 reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of NF-kB activation. J Pharmacol Exp Ther 332, 541-548 (2010)
  6. Ishida T, *Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kusumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T. Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis. Inflamm Bowel Dis 16, 87-95 (2010)
  7. Oushiki D, Kojima H, Terai T, Arita M, Hanaoka K, Urano Y, *Nagano T. Development and application of a near-infrared fluorescent probe for oxidative stress based on differential reactivity of linked cyanine dyes. J Am Chem Soc 132, 2795-2801 (2010)
  8. Seki H, Sasaki T, Ueda T, *Arita M. Resolvins as regulators of the immune system. Scientific World Journal 10, 818-831 (2010)

>> List


2009

  1. Ogawa S, Urabe D, Yokokura Y, Arai H, Arita M, *Inoue M. Total synthesis and bioactivity of resolvin E2. Org Lett 11, 3602-3605 (2009)
  2. Jin Y, Arita M, Zhang Q, Saban DR, Chauhan SK, Chiang N, Serhan CN, *Dana R. Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. Invest Opthalmol Vis Sci 50, 4743-4752 (2009)
  3. Seki H, Tani Y, *Arita M. Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostaglandins Other Lipid Mediat 89, 126-130 (2009)

>> List


2008

  1. Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, *Serhan CN. Resolvin E1, and EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood 112, 848-855 (2008)

>> List


2007

  1. Schwab JM, Chiang N, Arita M, *Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447, 869-874 (2007)
  2. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, *Serhan CN. Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation. J Immunol 178, 3912-3917 (2007)
  3. Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, *Colgan SP. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J 21, 3162-3170 (2007)
  4. *Bannenberg G, Arita M, Serhan CN. Endogenous receptor agonists: resolving inflammation. Scientific World Journal 7, 1440-1462 (2007)

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2006

  1. Arita M, Oh SF, Chonan T, Hong S, Elangovan S, Sun YP, Uddin J, Petasis NA, *Serhan CN. Metabolic inactivation of resolvin E1 and stabilization of its anti- inflammatory actions. J Biol Chem 281, 22847-22854 (2006)
  2. #Wada K, #Arita M, Nakajima A, Katayama K, Kudo C, Kamisaki Y, *Serhan CN. Leukotriene B4 and lipoxin A4 are counterregulatory signals for neural stem cell proliferation and differentiation. FASEB J 20, 1785-1792 (2006)  (# equal first authors)
  3. Fukunaga K, Arita M, Takahashi M, Morris AJ, Pfeffer M, *Levy BD. Identification and functional characterization of a presqualene diphosphate phosphatase. J Biol Chem 281, 9490-9497 (2006)
  4. Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio K, Hong S, Arita M, *Serhan CN. Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol 13, 1193-1202 (2006)
  5. Hasturk H, Kantarci IA, Ohira T, Arita M, Ebrahimi N, Petasis N, Levy BD, Serhan CN, *Van Dyke TE. RvE1 protects from local inflammation and osteoclast mediated bone destruction in periodontitis. FASEB J 20, 401-403 (2006)
  6. Shibata N, Jishage K, Arita M, Watanabe M, Kawase Y, Nishikawa K, Natori Y, Inoue H, Shimano H, Yamada N, Tsujimoto M, *Arai H. Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. FASEB J 20, 2642-2644 (2006)

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2005

  1. Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, *Serhan CN. Stereochemical assignment, anti-inflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 201, 713-722 (2005)
  2. Arita M, Yoshida M, Hong S, Tjonahen E, Glickman J, Petasis NA, Blumberg RS, *Serhan CN. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci USA 102, 7671-7676 (2005)
  3. Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger K, Hong S, *Serhan CN. Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol 174, 4345-4355 (2005)
  4. Chiang N, Arita M, *Serhan CN. Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins andtheir receptor ALX. Prostaglandins Leukot Essent Fatty Acids 73: 163-77 (2005)

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2004

  1. Ohira T, Bannenberg G, Arita M, Takahashi M, Ge Q, Van Dyke TE, Stahl GL, Serhan CN, *Badway JA. A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils. J Immunol 173, 2091-2098 (2004)
  2. *Serhan CN, Arita M, Hong S, Gotlinger K. Resolvins and protectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 39: 1125-1132 (2004)
  3. *Serhan CN, Gotlinger K, Hong S, and Arita M. Resolvins, Docosatrienes, and Neuroprotectins, novel omega-3 derived mediators, and their aspirin-triggered endogenous epimers: An overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat 73:155-72 (2004)

>> List


2003

  1. Devchand PR, Arita M, Hong S, Bannenberg GL, Moussignac RL, Gronert K, *Serhan CN. Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense. FASEB J 17, 652-659 (2003)
  2. Ariel A, Chiang N, Arita M, Petasis NA, *Serhan CN. Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. J Immunol 170, 6266-6272 (2003)
  3. Fierro IM, Colgan SP, Bernasconi G, Petasis NA, Clish CB, Arita M, *Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol 170, 2688-2694 (2003)
  4. Horiguchi M, Arita M, Kaempf-Rotzoll DE, Tsujimoto M, Inoue K, *Arai H. PH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes. Genes Cells 8:789-800 (2003)

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1995-2002

  1. *Yokota T, Igarashi K, Uchihara T, Jishage K, Tomita H, Inaba A, Li Y, Arita M, Suzuki H, Mizusawa H, Arai H. Delayed-onset ataxia in mice lacking alpha-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci USA 98:15185-90 (2001)
  2. Shibata N, Arita M, Misaki Y, Dohmae N, Takio K, Ono T, Inoue K, *Arai H. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Proc Natl Acad Sci USA 98:2244- 49 (2001)
  3. Jishage K, Arita M, Igarashi K, Iwata T, Watanabe M, Ogawa M, Ueda O, Kamada N, Inoue K, Arai H, *Suzuki H. Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice. J Biol Chem 276:1669-72 (2001)
  4. *Yokota T, Uchihara T, Kumagai I, Shiojiri T, Pang J, Arita M, Arai H, Hayashi M, Kiyosawa M, Okeda R, Mizusawa H. Postmortem study of ataxia with retinitis pigmentosa by mutation of the alpha-tocopherol transfer protein gene. J Neurol Neurosurg Psychiatry 68:521-25 (2000)
  5. Murakami M, Kambe T, Shimbara S, Higashino K, Hanasaki K, Arita H, Horiguchi M, Arita M, Arai H, Inoue K, *Kudo I. Different functional aspects of the group II subfamily (Type IIA and V) and type X secretory phospholipase A(2)s in regulating arachidonic acid release and prostagrandin generation. Implications of phospholipid scramblase-mediated cellular membrane perturbation. J Biol Chem 274:31435-44 (1999)
  6. Hosomi A, Goto K, Kondo H, Iwatsubo T, Yokota T, Ogawa M, Arita M, Aoki J, *Arai H, Inoue K. Localization of alpha-tocopherol transfer protein in rat brain. Neurosci Lett 256:159-62 (1998)
  7. Arita M, Sato Y, *Arai H, Inoue K. Binding of alpha-tocopherylquinone, an oxidized form of alpha-tocopherol, to glutathione-S-transferase in the liver cytosol. FEBS Lett 436:424-26 (1998)
  8. Kim H, Arai H, Arita M, Sato Y, Ogihara T, Inoue K, Mino M, *Tamai H. Effect of alpha-tocopherol status on alpha-tocopherol transfer protein expression and its messenger RNA level in rat liver. Free Rad Res 28:87-92 (1998)
  9. Arita M, Nomura K, *Arai H, Inoue K. Alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway.    Proc Natl Acad Sci USA 94:12437-41 (1997)
  10. Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, *Arai H, Inoue K. Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 409:105-8 (1997)
  11. *Yokota T, Shiojiri T, Gotoda T, Arita M, Arai H, Ohga T, Kanda T, Suzuki J, Imai T, Matsumoto H, Harino S, Kiyosawa M, Mizusawa H, Inoue K. Friedreich-like ataxia with retinis pigmentosa caused by the His101Gln mutation of the alpha-tocopherol transfer protein gene. Ann Neurol 41:826-37 (1997)
  12. Kim H, Arai H, Arita M, Sato Y, Ogihara T, Tamai H, Inoue K, *Mino M. Age-related changes of alpha-tocopherol transfer protein expression in rat liver. J Nutr Sci Vitaminol 42:11-18 (1996)
  13. Gotoda T, Arita M, Arai H, Inoue K, Yokota T, Fukuo Y, Yazaki Y, *Yamada N. Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer-protein. N Engl J Med 333:1313-18 (1995)
  14. Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M, Sokol R, Arai H, Inoue K, Mandel JL, *Koenig M. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 9:141-45 (1995)
  15. Arita M, Sato Y, Miyata A, Tanabe T, Takahashi E, Kayden HJ, Arai H, *Inoue K. Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Biochem J 306:437-43 (1995)