Making sense of gene networks
Human cells have the amazing ability to reprogram itself into another cell type by acquiring new genetic network or circuitry. For example, from skin fibroblasts into neurons. These ‘reprogrammed cells’ are applicable in regenerative medicine, disease modeling, and drug discovery. My laboratory focuses on developing OMICS technologies to profile the molecular make up in single cells - consisting of transcription factors, noncoding RNAs, and epigenetic factors - and elucidates the genetic circuitry through functional genomics approaches using CRISPR.