Laboratory for Human Immunogenetics

Our immune function is regulated by individual differences in the genome sequence (polymorphisms). Previous studies have identified that specific polymorphisms have causal roles in the onset of immune diseases, and drug discovery by genetics research (genetic drug discovery) is drawing attention. However, since the immune system is highly complex, the immunological functions of the risk polymorphisms have not been elucidated, and there are few successful cases of genetic drug discovery. Our laboratory aims to identify new drug targets through functional elucidation of the risk polymorphisms by utilizing the latest experimental techniques such as genome editing and single-cell multi-omics analysis.