Laboratory for Human Immunogenetics

PRINCIPAL INVESTIGATOR

Kazuyoshi Ishigaki (Team Director)

 

PERSONAL STATEMENTS

My research is focused on elucidating the mechanisms of human autoimmune diseases. My greatest strength is my multiple professional backgrounds: genetics, immunology, rheumatology, and bioinformatics. As a result, I can translate highly complex findings of basic science into clinically essential knowledge.

 

PRESENT POSITION

Team Leader, Laboratory for human immunogenetics,

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

 

RESEARCH EXPERIENCE

  • 2021-present:  Team Leader, Laboratory for Human Immunogenetics (RIKEN Center for Integrative Medical Sciences, Japan)

  1. Genome-editing based QTL fine-mapping analysis

  2. Single cell transcriptome analysis

  3. TCR repertoire and HLA association analysis

 

  • 2018-2021: Postdoctoral Researcher, The Raychaudhuri Lab (Harvard Medical School, Brigham And Women’s Hospital, Broad Institute, USA)

  1. TCR repertoire and HLA association analysis

  2. Functional annotations and their application to PRS

  3. TCR features in Tregs

  4. Single cell eQTL analysis

 

  • 2016-2018: Postdoctoral Researcher, Laboratory for Statistical Analysis (RIKEN Center for Integrative Medical Sciences, Japan)

  1. GWAS meta-analysis of rheumatoid arthritis in a Japanese population

  2. GWAS of 44 traits in Biobank Japan which includes more than 200K samples

 

  • 2014-2016: Postdoctoral Researcher, Laboratory for Autoimmune Diseases (RIKEN Center for Integrative Medical Sciences, Japan)

  1. eQTL analysis of primary immune cells from 105 individuals

  2. Transcriptome analysis (RNA-seq) of 20 primary immune cells in the peripheral blood of systemic lupus erythematosus patients

  3. Epigenome analysis (ChIP-seq) of synovium cells of rheumatoid arthritis patients

 

HONORS AND AWARDS

2018       Incentive Award, Annual General Assembly and Scientific Meeting of Japan College of Rheumatology, Tokyo, Japan

2017       Incentive Award, Annual Meeting of Japanese Society of Osteoimmunology, Okinawa, Japan