Genome-wide transcriptome studies such as FANTOM and ENCODE have shown that mammalian genomes are pervasively transcribed, generating a wide variety of transcript isoforms. Most transcripts do not code for proteins, but are though to have regulatory roles as non-coding RNAs. However, in most cases the specific biological function of non-coding RNAs is unknown. The Applied Computational Genomics Unit develops and applies bioinformatics methods to analyze genome-wide data generated using next-generation sequencers for the purpose of categorizing and functionally understanding RNA molecules, their role in biological networks, and the relation between non-coding RNA function and the 3D structure of mammalian genomes.
- Non-coding RNA
- Genome 3D structure