Laboratory for Advanced Biomolecular Engineering

Main Publications List

Origin of Life/RNA Polymerase

Original Papers

  1. An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins
  2. Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail
  3. Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion
  4. Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase
  5. Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function
  6. Structural basis for promoter specificity switching of RNA polymerase by a phage factor
  7. Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein

 

Reviews

  1. Computational protein design
  2. Why we are made of proteins and nucleic acids: Structural biology views on extraterrestrial life
  3. The origin of life: RNA and protein co-evolution on the ancient Earth

 

Peptides with Special Modifications

Original Papers

  1. Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin a v ß 3 in tumor imaging
  2. Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2
  3. Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway

 

Peptide Selection (Akira Wada)

  1. Development of Uniform Ribosome Display Technology Enabling Easy and Efficient Identification of Full-Length Proteins that Interact with Bioactive Small and Large Molecules
  2. Genetic Code Expansion and a Photo-Cross-Linking Reaction Facilitate Ribosome Display Selections for Identifying a Wide Range of Affinity Peptides
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