Genes associated with osteoarthritis: Identification of CALM1

March 3, 2005 PRESS RELEASE

The Laboratory for Bone and Joint Diseasesshowed that the CALM1 gene is associated with osteoarthritis onset. CALM1 is one of the genes coding for calmodulin, a protein that plays a key role in intracellular signaling, and is thought to be involved in the communication of mechanical stress in the cartilage. The Laboratory discovered that there are combined effects from the CALM1 polymorphism and the osteoarthritis-associated asporin.
The research results were published in the online version of the UK science journal Human Molecular Genetics on March 3, 2005.