Activation Mechanism of Lymphatic Corpuscles Elucidated

June 18, 2003 PRESS RELEASE

The Laboratory for Lymphocyte Differentiation and the Kansai Medical University has elucidated activation mechanism of lymphocytes responsible for antibody production and immunity.
The laboratory noticed the functions of adaptor molecule group, one of the signal molecules responsible for lymphocyte activation when cells responding to external stimulation. They verified that lymphocytes are regulated by the switching on and off of a guanosine triphosphate (GTP)-binding molecule, Rac, and that two adapter molecules are involved in Rac activation in coordination. It is said that promotion of research on these molecular groups can be expected to bring about development of immunity and allergy control medicines. This research result was published in the U.S. science journal “Immunology”.