Laboratory for Advanced Genomics Circuit

Making sense of gene networks


Team Leader
Jay W. SHIN,  Ph.D.

1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045


Research Area

Human cells have the amazing ability to reprogram itself into another cell type by acquiring new genetic network or circuitry. For example, from skin fibroblasts into neurons. These ‘reprogrammed cells’ are applicable in regenerative medicine, disease modeling, and drug discovery. My laboratory focuses on developing OMICS technologies to profile the molecular make up in single cells - consisting of transcription factors, noncoding RNAs, and epigenetic factors - and elucidates the genetic circuitry through functional genomics approaches using CRISPR.



  1. SHIN TL gave a talk on HCA at Ehime University (JPN page)
  2. TEDx Kobe – "More to our Junk DNA than meets the eye"
  3. 1st HCA Asia Meeting in Okinawa Japan
  4. FANTOM session at HUGO meeting in Yokohama