Laboratory for Applied Computational Genomics

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Team Leader
Michiel DE HOON  Ph.D.

1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045

michiel.dehoon[at]riken.jp

Research Area

Genome-wide transcriptome studies such as FANTOM and ENCODE have shown that mammalian genomes are pervasively transcribed, generating a wide variety of transcript isoforms. Most transcripts do not code for proteins, but are though to have regulatory roles as non-coding RNAs. However, in most cases the specific biological function of non-coding RNAs is unknown. The Applied Computational Genomics Unit develops and applies bioinformatics methods to analyze genome-wide data generated using next-generation sequencers for the purpose of categorizing and functionally understanding RNA molecules, their role in biological networks, and the relation between non-coding RNA function and the 3D structure of mammalian genomes.

Research Subjects:

  • Non-coding RNA
  • FANTOM6
  • Genome 3D structure
  • Bioinformatics