RIKEN IMS AnnualReport 2020
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88 213 Tsugawa H, Ikeda K, Takahashi M, Satoh A, Mori Y, Uchino H, Okahashi N, Yamada Y, Tada I, Bonini P, Higashi Y, Okazaki Y, Zhou Z, Zhu Z, Koelmel J, Cajka T, Fiehn O, Saito K, Arita M, Arita M. A lipidome atlas in MS-DIAL 4. Nat Biotechnol 38, 1159-1163 (2020) 214 Tuganbaev T, Mor U, Bashiardes S, Liwinski T, Nobs SP, Leshem A, Dori-Bachash M, Thaiss CA, Pinker EY, Ratiner K, Adlung L, Federici S, Kleimeyer C, Moresi C, Yamada T, Cohen Y, Zhang X, Massalha H, Massasa, Kuperman Y, Koni PA, Harmelin A, Gao N, Itzkovitz S, Honda K, Shapiro H, Elinav E. Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis. Cell 182, 1441-1459.e21 (2020) 215 Unoki M, Sharif J, Saito Y, Velasco G, Koseki H, Sasaki H. CDCA7 and HELLS suppress DNA: RNA hybrid-associated DNA damage at pericentromeric repeats. Sci Rep 10, 17865 (2020) 216 Utsunomiya A, Chino T, Utsunomiya N, Tokuriki A, Naganuma T, Arita M, HIgashi K, Saito K, Suzuki N, Ohara A, Sugai M, Sugawara K, Tsuruta D, Oyama N, Hasegawa M. Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. J Invest Dermatol 140, 838-849.e9 (2020) 217 Wagner M, Ealey KN, Tetsu H, Kiniwa T, Motomura Y, Moro K, Koyasu S. Tumour-derived lactic acid contributes to the paucity of intratumoural ILC2s. Nat Commun 30, 2743-2757.e5 (2020) 218 Wardah W, Dehzangi A, Taherzadeh G, Rashid MA, Khan M, Tsunoda T, Sharma A. Predicting protein-peptide binding sites with a Deep Convolutional Neural Network. J Theor Biol 496, 110278 (2020) 219 Watanabe E, Kawashima Y, Suda W, Kakihara T, Takazawa S, Nakajima D, Nakamura R, Nishi A, Suzuki K, Ohara O, Fujishiro J. Discovery of Candidate Stool Biomarker Proteins for Biliary Atresia Using Proteome Analysis by Data-Independent Acquisition Mass Spectrometry. Proteomes 8, 36 (2020) 220 Watanabe K, Morohoshi S, Kunihiro T, Ishii Y, Takayasu L, Ogata Y, Suda W. Fluviibacter phosphoraccumulans gen. nov., sp. nov., a polyphosphate accumulating bacterium isolated from surface river water. Int J Syst Evol Microbiol 70, 5551-5560 (2020) 221 Watanabe T, Nadatani Y, Suda W, Higashimori A, Otani K, Fukunaga S, Hosomi S, Tanaka F, Nagami Y, Taira K, Tanigawa T, Nakatsu G, Hattori M, Fujiwara Y. Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer. Gastric Cancer (Epub 2020) 222 Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K. Bidirectional crosstalk between neutrophils and adipocytes promotes adi-pose tissue inflammation. FASEB J 33, 11821-11835 (2020) 223 Yakneen S, Waszak S, PCAWG Technical Working Group, Gertz M, Korbel J, PCAWG Consortium, Nakagawa H, Boroevich KA, Fujimoto A, Fujita M, Furuta M, Maejima K, Nakano K, Oku-Sasaki A, Johnson TA, Tsunoda T, Lawrence MS. Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol 38, 288-292 (2020) 224 Yamamoto K, Sakaue S, Matsuda K, Murakami Y, Kamatani Y, Ozono, Momozawa Y, Okada. Genetic and phenotypic landscape of the mitochondrial genome in the Japa-nese population. Commun Biol 3, 104 (2020) 225 Yamamoto K, Suzuki A, Harada N, Shoda H, Hatano H, Nagafuchi Y, Komai T, Okamura T, Gunarta I, Yoshioka K, Fujio K. Peptidylarginine deiminase 4 promotes the renal infiltration of neutrophils and exacerbates the TLR7 agonist-induced lupus mice has been approved for production. Front Immunol 11, 1095 (2020)genetic risk of rheumatoid arthritis. Ann Rheum Dis (Epub 2020) 226 Yamamoto T, Miyata J, Arita M, Fukunaga K, Kawana A. Current state and future prospect of the therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma. Respir Investig 57, 534-543 (2020) 227 Yang K, Inoue A, Lin F. Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorga-nization, developmental defects in preimplantation embryos and impaired female fertility. Sci Rep 9, 18875 (2020) 228 Yannic BC, Simon E, Alexei L, Hanna LB, Sander W, Janina P, Gina-Maria L, Johann R, Noortje Hd, Alexandra H, Raghu E, Anastasios GD, Lilian A, Ryota S, Louise A d, Andre W, Dominique B, Juliane H, Kyra K, Vanessa K, Moritz S, Veronique B, Timo G, Jens HK, Mattias C, Gabriela S, Rudolf MA, Fukuyama H, Thomas K, Ari W, Nir Y, Samuel H, Bjorn R, Stefan R, Hauke B, Friederike B, Christoph H, Manfred W, Marc E. IgG Fc Sialylation Is Regulated During the Germinal Center Reaction Upon Immunization With Different Adjuvants. J Allergy Clin Immunol 146, 652-666.e11 (2020) 229 Yasuda S, Okahashi N, Tsugawa H, Ogata Y, Ikeda K, Suda W, Arai H, Hattori M, Arita M. Elucidation of gut microbiota-associated lipids using LC-MS/MS and 16S rRNA sequence analyses. iScience 23, 101841 (2020) 230 Yasuda-Sekiguchi F, Shiohama A, Fukushima A, Obata S, Mochimaru N, Honda A, Ka-wasaki H, Kubo A, Ebihara T, Amagai M, Sasaki T. Single nucleotide variations in genes associated with innate immunity are enriched in Japanese adult cases of face and neck type atopic dermatitis. J Dermatol Sci S0923-1811(20)30354-62020 231 Yasukawa M, Ando Y, Yamashita T, Matsuda Y, Shoji S, Morioka MS, Hideya K, Shio-zawa K, Machitani M, Abe T, Yamada S, Kaneko MK, Kato Y, Furuta Y, Kondo T, Shirouzu M, Hayashizaki Y, Kaneko S, Masutomi K. CDK1 dependent phosphorylation of hTERT contributes to cancer progression. Nat Commun 1, 2020 (2020) 232 Yasuoka Y. 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Nat Genet 52, 342-352 (2020) 236 Zagato E, Pozzi, Bertocchi A, Schioppa T, Saccheri F, Guglietta S, Fosso B, Melocchi L, Nizzoli G, Troisi, Marzano M, Oresta B, Spadoni I, Atarash K, Carloni S, Arioli S, Fornasa G, Asnicar F, Segata N, Guglielmetti S, Honda K, Pesole G, Vermi W, Penna, Rescigno M. Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth. Nat Microbiol 5, 511-524 (2020) 237 Zapatka M, Borozan I, Brewer D, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H, PCAWG Pathogens, Cooper C, Eils R, Ferretti V, Lichter P, PCAWG Consortium, Nakagawa H, Boroevich KA, Fujimoto A, Fujita M, Furuta M, Maejima K, Nakano K, Oku-Sasaki A, Johnson TA, Tsunoda T, Lawrence MS. The landscape of viral associations in human cancers. 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