RIKEN IMS AnnualReport 2020
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J Med Chem 63, 987-1001 (2020) 75 Jiao W, Atwal G, Polak P, Karlic R, Cuppen E, PCAWG TumorSubtypes and Clinical Translation Working Group, Danyi A, de Ridder J, van Herpen C, Lolkema M, Steeghs N, Getz G, Morris Q, Stein L, PCAWG Consortium, Nakagawa H, Boroevich KA, Fujimoto A, Fujita M, Furuta M, Maejima K, Nakano K, Oku-Sasaki A, Johnson TA, Tsunoda T, Law-rence MS. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun 11, 728 (2020) 76 Jodo A, Shibazaki A, Onuma A, Kaishi T, Tanaka T. PDLIM7 synergizes with PDLIM2 and p62/Sqstm1 to inhibit inflammatory signaling by promoting degradation of the p65 subunit of NF-κB. Front Immunol 11, 1559 (2020) 77 Johnson TA, Mashimo Y, Wu J, Dankyu Y, Hata A, Kubo, Takahashi A, Tsunoda T, Ozaki K, Tanaka T, Ito K, Suzuki H, Hamada H, Kobayashi T, Hara T, Chen C, Lee Y, Liu Y, Chang L, Chang C, Hong Y, Jang G, Yun S, Yu J, Lee K, Kim J, Park T, Lee J, Chen Y, Onouchi Y. Association of an IGHV3-66 gene variant with Kawasaki disease. J Hum Genet (Epub 2020) 78 Johnson TA, Mashimo Y, Wu J, Dankyu Y, Hata A, Kubo, Takahashi A, Tsunoda T, Ozaki K, Tanaka T, Ito K, Suzuki H, Hamada H, Kobayashi T, Hara T, Chen C, Lee Y, Liu Y, Chang L, Chang C, Hong Y, Jang G, Yun S, Yu J, Lee K, Kim J, Park T, Lee J, Chen Y, Onouchi Y. Association of an IGHV3-66 gene variant with Kawasaki disease. J Hum Genet Oct 26, 1-15 (2020) 79 Kajihara D, Hon C, Abdullah AN, Wosniak Jr J, Moretti AS, F. Poloni J, Bonatto D, Hashimoto K, Carninci P, Laurindo FR. Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene. BMC Genomics 21, 766 (2020) 80 Kanaya T, Williams IR, Ohno H. Intestinal M Cells: Tireless Samplers of Enteric Micro-biota. Traffic 21, 34-44 (2020) 81 Kato M, Carninci P. Genome-wide technologies to study RNA–chromatin interactions. Noncoding RNA 6, 20 (2020) 82 Kawamura T, Imamura CK, Kenmotsu H, Taira T, Omori S, Nakashima K, Wakuda K, Ono A, Naito T, Murakami H, Mushiroda T, Takahashi T, Tanigawara Y. Evaluation of gefitinib systemic exposure in EGFR-mutated non-small cell lung cancer patients with gefitinib-induced severe hepatotoxicity. Cancer Chemother Pharmacol 85, 605-614 (2020) 83 Kelly ST, Black MA. graphsim: An R package for simulating gene expression data from graph structures of biological pathways. JOSS 5, 2161 (2020) 84 Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice. Science 367, eaaw8429 (2020) 85 Kitajima M, Kubo M, Ziegler SF, Suzuki H. Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation. J Immunol 205, 27-35 (2020) 86 Kitami T, Fukuda S, Kato T, Yamaguti K, Nakatomi Y, Yamano E, Kataoka Y, Mizuno K, Tsuboi Y, Suzuki H, Ito M, Morioka MS, Kawaji H, Koseki H, Kikuchi J, Hayashizaki Y, Ohno H, Kuratsune H, Watanabe Y. Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population. Sci Rep 1, 19933 (2020) 87 Kitami T, Fukuda S, Kato T, Yamaguti K, Nakatomi Y, Yamano E, Kataoka Y, Mizuno K, Tsuboi Y, Suzuki H, Ito M, Morioka MS, Kawaji H, Koseki H, Kikuchi J, Hayashizaki Y, Ohno H, Kuratsune H, Watanabe Y. Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population. Sci Rep 10, 19933 (2020) 88 Kobayashi T, Ricardo-Gonzalez R, Moro K. Skin-Resident Innate Lymphoid Cells - Cuta-neous Innate Guardians and Regulators. Trends Immunol 41, 100-112 (2020) 89 Kojima S, Parrish N, Terao C. Chromosomally-integrated human herpesvirus 6 and autoimmune connective tissue diseases. J Clin Virol 134, 104714 (2020) 90 Kojo S, Ohno-Oishi M, Wada H, Nieke S, Seo W, Muroi S, Taniuchi I. Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells. Life Sci Alliance 3, e202000642 (2020) 91 Kokaji T, Hatano A, Ito Y, Yugi K, Eto M, Morita K, Ohno S, Fujii M, Hironaka K, Egami R, Terakawa A, Tsuchiya T, Ozaki H, Inoue H, Uda S, Kubota H, Suzuki Y, Ikeda K, Arita M, Matsumoto M, Nakayama KI, Hirayama A, Soga T, Kuroda S. Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity. Sci Signal 13, eaaz1236 (2020) 92 Koseki K, Kawasaki H, Atsugi T, Nakanishi M, Mizuno M, Naru E, Ebihara T, Amagai M, Kawakami E. Assessment of skin barrier function using skin images with topological data analysis. NPJ Syst Biol Appl 6, 40 (2020) 93 Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo J, Higasa K, Iwasaki M, Yamaji T, Sawada N, Tsugane S, Koyama T, Ikezaki H, Takashima N, Tana-ka K, Arisawa K, Kuriki K, Naito M, Wakai K, Suna S, Sakata Y, Sato H, Hori M, Sakata Y, Matsuda K, Murakami Y, Aburatani H, Kubo M, Matsuda F, Kamatani Y, Komuro I. Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease. Nat Genet 52, 1169-1177 (2020) 94 Koyanagi Y, Ueno S, Ito Y, Kominami T, Komori S, Akiyama M, Murakami Y, Ikeda Y, So-noda K, Terasaki H. Relationship Between Macular Curvature and Common Causative Genes of Retinitis Pigmentosa in Japanese Patients. Invest Ophthalmol Vis Sci 61, 6 (2020) 95 Kubo M, Miyauchi K. Breadth of Antibody Responses during Influenza Virus Infection and Vaccination. Trends Immunol 41, 394-405 (2020) 96 Kubo M. Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3. Front Immunol 11, 552188 (2020) 97 Kureha T, Miyao T, Nishijima S, Suzuki T, Koizumi S, Villar-Briones A, Takahashi A, Aki-yama N, Morita M, Naguro I, Ishikawa H, Ichijo H, Akiyama T, Yamamoto T. The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. Nat Commun 11, 6169 (2020) 98 Lee-Thacker S, Jeon H, Choi Y, Taniuchi I, Takarada T, Yoneda Y, Ko C, Jo M. Core Binding Factors Are Essential for Ovulation, Luteinization, and Female Fertility in Mice. Sci Rep 10, 9921 (2020) 99 Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N, PCAWG Tumour Subtypes and Clinical Translation, Boutros PC, PCAWG Consortium. Sex differences in oncogenic mutational processes. 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