In 2020, the laboratory for Integrative Genomics went through two major 41Provided by Integrated Genomics TeamSample PrepSequencerBioinformaticsWhole genome sequenceSingle cell RNA-seqRamDA-seqSMART-seq2Bulk RNA-seqCAGETarget SequenceGenotypingLuminexIlluminaNovaSeqHiSeqMiSeqRamDA-seqSMART-seq2BCR-seqTCR-seqMGIPacBioFASTQRNA-seqSmart-seq2ChIP-seqATAC-seqData registrationBCR-seqTCR-seqtransitions: change in leadership and change in the framework for core-laboratory function. At the end of March 2020, Dr. Ohara retired from his team leader position. From the beginning of the Research Center for Allergy and Immunology (RCAI) in 2001, Dr. Ohara has been leading this laboratory for almost 20 years and been building the fundamental structure of the lab, where the lab members have been exploring original research as well as providing core laboratory functions to the entire institute. On Oct 1st, Dr. Jun Seita assumed the team leader position and a new era has begun.After several mergers, IMS is now much larger than the original RCAI, and an efficient structure to provide core-laboratory functions had to be different. In 2020, the Center introduced a “Platform”, framework for core-laboratory functions and we have participated in the “Genome Platform” launched at the end of September. As shown in the Figure, the “Genome Platform” provides technologies and methodologies around DNA and RNA, and we mainly pro-vide various solutions for single cell RNA seq.Genomics technology and methodology are currently evolving even faster than before, especially towards single-cell resolution. We will keep pursuing cutting-edge approaches in genomics, implementing new technologies and methodologies, and providing such solutions to all IMS researchers via the Ge-nome Platform.Figure: Solutions provided by the IMS Genome PlatformVarious technologies and methodologies are available to all IMS researchers via the IMS Genome Platform (as of Feb 2021). The laboratory for Integrative Genomics provides single-cell RNA-seq technologies and T cell and B cell antigen receptor-related assays.Recent Major PublicationsOkada M, Shimizu K, Iyoda T, Ueda S, Shinga J, Mochizuki Y, Watanabe T, Ohara O, Fujii SI. PD-L1 Expression Affects Neoantigen Presentation. iScience 23, 101238 (2020)Nishizono H, Darwish M, Endo TA, Uno K, Abe H, Yasuda R. Glycine receptor α4 subunit facilitates the early em-bryonic development in mice. Reproduction 159, 41-48 (2020)Yazaki J. Novel Protein-oligonucleotide Conjugation Method Involving a High-affinity Capture HaloTag. Bio Protoc 10, e3759 (2020)Invited presentationsSeita J. “Toward data-driven medical sciences” Educa-tional Lecture at the 5th Annual Meeting of the Society of Internet of Medical Things (Virtual) December 2020Seita J. “Deep Learning for Medicine” Symposium at the 50th Annual Meeting of the Japanese Society for Cutaneous Immunology and Allergy (Kochi, Japan) De-cember 2020Seita J. “Now and future of AI in Medicine” Keynote Lec-ture at the 61st Annual Meeting of Japanese College of Angiology (Virtual) October 2020IMS Genome PlatformLaboratory for Integrative GenomicsTeam Leader: Jun Seita
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