Lipids constitute biological membranes and play a variety of other roles as 46Non-targeted lipidomicsLipidome AtlasSpatial transcriptomics/proteomicsSpatial lipidiomicsBiology & Diseaseenergy sources, signaling molecules, and their precursors. Some lipids are biologically active as single molecules, while others are involved in the forma-tion of membrane domains as molecular assemblies. Since lipids are extremely diverse molecules, the precise determination of different molecular species of lipid, a process we have termed “LipoQuality”, is important for understanding their functions in physiology and disease, and for discovering novel bioac-tive lipids that may have therapeutic benefits. In general, dysregulated lipid metabolism is associated with diseases such as obesity, atherosclerosis, stroke, hypertension, and diabetes, and hence there is great interest in furthering our understanding of how lipids behave within complex biological systems. We aim to elucidate the mechanisms that create, regulate, and recognize lipid diversity as a spatiotemporal system by constructing a “Lipidome Atlas”, as well as to identify diseases caused by its disturbance. The discovery of the significance of lipid molecules involved in various life phenomena and their diversity through non-targeted, highly accurate, and in-depth original technologies is expected to have a ripple effect on a wide range of life science fields and contribute to medi-cal science and a healthy and long-lived society based on scientific evidence.Figure: Innovative lipidomics for creation of the Lipidome AtlasWe aim to elucidate the mechanisms that create, regu-late and recognize lipid diversity and its localization in vivo, and to identify diseases caused by the disruption of such mechanisms. The Lipidome Atlas will facilitate the discovery of new biological systems shaped by lipid diversity, leading to an integrated understanding of lipid-centric biology.Recent Major PublicationsKuroha S, Katada Y, Isobe Y, Uchino H, Shishikura K, Ni-rasawa T, Tsubota K, Negishi K, Kurihara T, Arita M. Long chain acyl-CoA synthetase 6 facilitates the local distribu-tion of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice. FASEB J 37, e23151 (2023)Iino Y, Naganuma T, Arita M. Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1. J Lipid Res 64, 100329 (2023)Uchino H, Tsugawa H, Takahashi H, Arita M. Computa-tional mass spectrometry accelerates C=C position-re-solved untargeted lipidomics using oxygen attachment dissociation. Commun Chem 5, 162 (2022) selected in 2022 Editor’s HighlightsInvited presentationsArita M. “Introduction of the JST-ERATO Lipidome Atlas Project in Japan” 63rd International Congress on the Bio-science of Lipids (ICBL2023) (Palma de Mallorca, Spain) October 2023Arita M. “Advanced lipidomics technology reveals the biology of lipid diversity and disease control” IDIBAPS Seminar Series (Barcelona, Spain) September 2023Arita M. “Advanced lipidomics technology reveals the biology of lipid diversity and disease control” The 82nd Annual Meeting of the Japanese Cancer Association (Yokohama, Japan) September 2023Arita M. “Advanced lipidomics technology reveals the biology of lipid diversity and disease control” 11th International Singapore Lipid Symposium (iSLS11) (Sin-gapore) March 2023Arita M. “Advanced lipidomics technology reveals the biology of lipid diversity and disease control” 6th International Symposium of Kyoto Biomolecular Mass Spectrometry Society (Kyoto, Japan) January 2023Laboratory for MetabolomicsTeam Leader: Makoto Arita
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