94CoverHuman dermal fibroblasts exogenously expressing ATP8 N-terminally fused with mitochondrial targeting sequence of ATP5MC1 and C-terminally FLAG-tagged. ATP8-FLAG proteins were properly localized to mitochondria as detected by im-munostaining. Green, ATP8-FLAG; magenta, mitochondria; blue, nuclei.Credit to Dr. Yuuri YasuokaLaboratory for Comprehensive Genomic AnalysisFront page of Part 2Chromosome spindle in a mouse unfertilized egg. Green: Tubulin. Pur-ple: DNA. White: Centromere.Credit to Dr. Azusa InoueLaboratory for Epigenome InheritanceFront page of Part 4Chromosome spread of a mouse unfertilized egg. Chromosomes were stained with DAPI (blue) and kinetochores were labeled with CREST (red).Credit to Dr. Azusa InoueLaboratory for Epigenome InheritanceFront page of Part 1Cytopathic effect with syncytia formation by measles virus infection. Vero cells, immortalized African green monkey cells, expressing human SLAM were infected with measles virus carrying EGFP gene.Credit to Dr. Shohei KojimaGenome Immunobiology RIKEN Hakubi Research TeamFront page of Part 3This alluvial plot shows that the plasma cytokines significantly mediate the effects of fecal carbohydrates on host clinical metabolic markers. The lines and their width show the media-tion effects and its strength, and different colors represent the associations mediated by individual cytokines. HOMA-IR, homeostasis model assessment of insulin resistance; BMI, body mass index; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol.Credit to Dr. Hiroshi OhnoLaboratory for Intestinal EcosystemFront page of Part 5A Xenopus tropicalis tadpole injected with antisense morpholino oli-gos, which inhibit chst1 translation. It catalyzes the sulfation of galac-tose within keratan sulfate proteoglycans in otic vesicles. Loss of chst1 resulted in dwarfing of otic vesicles.Credit to Dr. Yuuri YasuokaLaboratory for Comprehensive Genomic AnalysisOriginal Photos of the Cover and Front Pages
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