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92 209 Satoh-Takayama N, Ohno H. Unraveling the Heterogeneity and Specialization of ILCs. 210 Sekine Y, Iwasaki Y, TAoi T, Endo M, Hirata M, Kamatani Y, Matsuda K, Sugano K, Yo-shida T, Murakami Y, Fukui T, Akamatsu S, Ogawa O, Nakagawa H, Numakura K, Narita S, Habuchi T, Momozawa Y. Different risk genes contribute to clear cell and non-clear cell renal cell carcinoma in 1,532 Japanese patients and 5,996 controls. Human Mo-lecular Genetics, doi.org/10.1093/hmg/ddab345 (Epub 2021) 211 Sharma A, Lysenko A, Boroevich KA, Vans E, Tsunoda T. DeepFeature: feature selection in nonimage data using convolutional neural network. Brief Bioinform 22, bbab297 (2021) 212 Sheng G, Carninci P, Siomi MC, Suda T, Alev C. Japan: prize diversity, not conformity, to 213 Shi Z, Ohno H, Satoh-Takayama N. Dietary Derived Micronutrients Modulate Immune 214 Shimasaki T, Masuda S, Garrido-Oter R, Kawasaki T, Aoki Y, Shibata A, Suda W, Shirasu K, Yazaki K, Nakano RT, Sugiyama A. Tobacco Root Endophytic Arthrobacter Harbors Genomic Features Enabling the Catabolism of Host-Specific Plant Specialized Metabo-lites. mBio 12, e0084621 (2021) 215 Shimizu K, Iyoda T, Sanpei A, Nakazato H, Okada M, Ueda S, Kato-Murayama M, Mu-rayama K, Shirouzu M, Harada N, Hidaka M, Fujii SI. Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2. Commun Biol 4, 1365 (2021) 216 Shimizu T, Nagafuchi Y, Harada H, Tsuchida Y, Tsuchiya H, Hanata N, Tateishi S, Kanda H, Sumitomo S, Shoda H, Yamamoto K, Fujio K. Decreased peripheral blood memory B cells are associated with the presence of interstitial lung disease in rheumatoid arthri-tis: a case-control study. Mod Rheumatol 31, 127-132 (2021) 217 Shinnakasu R, Sakakibara S, Yamamoto H, Wang PH, Moriyama S, Sax N, Ono C, Yamanaka A, Adachi Y, Onodera T, Sato T, Shinkai M, Suzuki R, Matsuura Y, Hashii N, Takahashi Y, Inoue T, Yamashita K, Kurosaki T. Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related vi-ruses. J Exp Med 218, e20211003 (2021) 218 Shinoda D, Nakajima-Takagi Y, Oshima M, Koide S, Aoyama K, Saraya A, Harada H, Rahmutulla B, Kaneda A, Yamaguchi K, Furukawa Y, Koseki H, Shimoda K, Tanaka T, Sashida G, Iwama A. Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis. Leukemia 36, 452-463 (2021) 219 Shiohira H, Fukunaga K, Tayag JCS, Tamashiro Y, Mushiroda T, Nakamura K. Effect of 5-fluorouracil on mRNA expression of drug metabolizing enzyme and transporter genes in human hepatoma cell lines. Biomed Res 42, 121-127 (2021) 220 Shiraga K, Urabe M, Matsui T, Kikuchi S, Ogawa Y. Highly precise characterization of the hydration state upon thermal denaturation of human serum albumin using a 65 GHz dielectric sensor. Phys Chem Chem Phys 22, 19468-19479 (2021) 221 Sonehara K, Sakaue S, Maeda Y, Hirata J, Kishikawa T, Yamamoto K, Matsuoka H, Yoshimura M, Nii T, Ohshima S, Kumanogoh A, Okada Y. Genetic architecture of mi-croRNA expression and its link to complex diseases in the Japanese population. Hum Mol Genet, doi: 10.1093/hmg/ddab361 (Epub 2021) 222 Spracklen C, Horikoshi M, Kim Y, Lin K, Bragg F, Moon S, Suzuki K, Tam C, Tabara Y, Kwak S, Takeuchi F, Long J, Lim V, Chai J, Chen C, Nakatochi M, Yao J, Choi H, Iyengar A, Perrin H, Brotman S, van de Bunt M, Gloyn A, Below J, Boehnke M, Bowden D, Cham-bers J, Mahajan A, McCarthy M, Ng M, Petty L, Zhang W, Morris A, Adair L, Akiyama M, Bian Z, Chan J, Chang L, Chee M, Chen Y, Chen Y, Chen Z, Chuang L, Du S, Gordon-Larsen P, Gross M, Guo X, Guo Y, Han S, Howard A, Huang W, Hung Y, Hwang M, Hwu C, Ichihara S, Isono M, Jang H, Jiang G, Jonas J, Kamatani Y, Katsuya T, Kawaguchi T, Khor C, Kohara K, Lee M, Lee N, Li L, Liu J, Luk A, Lv J, Okada Y, Pereira M, Sabanayagam C, Shi J, Shin D, So W, Takahashi A, Tomlinson B, Tsai F, van Dam R, Xiang Y, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan J, Zhang L, Zheng W, Igase M, Cho Y, Rotter J, Wang Y, Sheu W, Yokota M, Wu J, Cheng C, Wong T, Shu X, Kato N, Park K, Tai E, Matsuda F, Koh W, Ma R, Maeda S, Millwood I, Lee J, Kadowaki T, Walters R, Kim B, Mohlke K, Sim X. Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature 582, 240-245 (2021) 223 Suda W, Ogata Y, Takayasu L, Shindo C, Watanabe K. Complete Genome and Plasmid Sequences of Three Fluviibacter phosphoraccumulans Polyphosphate-Accumulating Bacterioplankton Strains Isolated from Surface River Water. Microbiol Resour An-nounc 10, e01474-20 (2021)RJ, Hirose N, Honda K. Novel bile acid biosynthetic pathways are enriched in the mi-crobiome of centenarians. Nature 599, 458-464 (2021)Immunity 53, 699-701 (2021)boost research. Nature 599, 201 (2021)Responses Through Innate Lymphoid Cells. Front Immunol 12, 670632 (2021) 224 Sudo T, Motomura Y, Okuzaki D, Hasegawa T, Yokota T, Kikuta J, Ao T, Mizuno H, Matsui T, Motooka D, Yoshizawa R, Nagasawa T, Kanakura Y, Moro K, Ishii M. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. J Exp Med 218, e20200817 (2021) 225 Suetsugu H, Kim K, Yamamoto T, Bang SY, Sakamoto Y, Shin JM, Sugano N, Kim JS, Mukai M, Lee YK, Ohmura K, Park DJ, Takahashi D, Ahn GY, Karino K, Kwon YC, Mi-yamura T, Kim J, Nakamura J, Motomura G, Kuroda T, Niiro H, Miyamoto T, Takeuchi T, Ikari K, Amano K, Tada Y, Yamaji K, Shimizu M, Atsumi T, Seki T, Tanaka Y, Kubo T, Hisada R, Yoshioka T, Yamazaki M, Kabata T, Kajino T, Ohta Y, Okawa T, Naito Y, Kaneuji A, Yasunaga Y, Ohzono K, Tomizuka K, Koido M, Matsuda K, Okada Y, Suzuki A, Kim BJ, Kochi Y, Lee HS, Ikegawa S, Bae SC, Terao C. Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus. Hum Mol Genet, doi: 10.1093/hmg/ddab306 (Epub 2021) 226 Sugimoto R, Nishimura L, Nguyen PT, Ito J, Parrish NF, Mori H, Kurokawa K, Nakaoka H, Inoue I. Comprehensive discovery of CRISPR-targeted terminally redundant sequences in the human gut metagenome: Viruses, plasmids, and more. PLoS Comput Biol 17, e1009428 (2021) 227 Sugishita H, Kondo T, Ito S, Nakayama M, Yakushiji-Kaminatsui N, Kawakami E, Koseki Y, Ohinata Y, Sharif J, Harachi M, Blackledge NP, Klose RJ, Koseki H. Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactiva-tion at target genes. Nat Commun 12, 5341 (2021) 228 Sun C, Nagaoka K, Kobayashi Y, Nakagawa H, Kakimi K, Nakajima J. Neoantigen den-dritic cell vaccination combined with anti-CD38 and CpG elicits anti-tumor immunity against the immune checkpoint therapy-resistant murine lung cancer cell line LLC1. Cancers 13, 5508 (2021) 229 Sun M, Wang Y, Zheng C, Wei Y, Hou J, Zhang P, He W, Lv X, Ding Y, Liang H, Hon CC, Chen X, Xu H, Chen Y. Systematic functional interrogation of human pseudogenes us-ing CRISPRi. Genome Biol 22, 240 (2021) 230 Suzuki A, Yamamoto K, Guerrini MM. Functional genomics of autoimmune diseases. Ann Rheum Dis, doi: 10.1136/annrheumdis-2019-216794 (Epub 2021) 231 Suzuki T, Koike Y, Ashikawa K, Otomo N, Takahashi A, Aoi T, Kamatani N, Nakamura Y, Kubo M, Kamatani Y, Momozawa Y, Terao C, Yamakawa K. Genome-wide association study of epilepsy in a Japanese population identified an associated region at chromo-some 12q24. Epilepsia 62, 1391-1400 (2021) 232 Suzuki T, Nakamura Y, Doi Y, Narita A, Shimizu A, Imaeda N, Goto C, Matsui K, Kadota A, Miura K, Nakatochi M, Tanaka K, Hara M, Ikezaki H, Murata M, Takezaki T, Nishimoto D, Matsuo K, Oze I, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Watanabe M, Suzuki S, Katsuura-Kamano S, Arisawa K, Kuriki K, Momozawa Y, Kubo M, Takeuchi, Kita Y, Wakai K. A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study. Br J Nutr 126, 1843-1851 (2021) 233 Suzuki Y, Sasamoto, Koyama T, Yoshijima, Oda A, Nakatochi M, Kubo, Momozawa Y, Uehara R, Ohno K. Relationship of hemoglobin level and plasma coproporphyrin-I concentrations as an endogenous probe for phenotyping OATP1B. Clin Transl Sci 14, 1403-1411 (2021) 234 Syed KM, Hon CC. Heterogeneity among enhancer RNAs: origins, consequences and perspectives. Essays Biochem 65, 709-721 (2021) 235 Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipo-tency. Nat Commun 12, 5041 (2021) 236 Takada Y, Yaman-Deveci R, Shirakawa T, Sharif J, Tomizawa SI, Miura F, Ito T, Ono M, Nakajima K, Koseki Y, Shiotani F, Ishiguro KI, Ohbo K, Koseki H. Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating ho-mologous chromosome pairing. Development 148, dev194605 (2021) 237 Takahashi D, Hoshina N, Kabumoto Y, Maeda Y, Suzuki A, Tanabe H, Isobe J, Yamada T, Muroi K, Yanagisawa Y, Nakamura A, Fujimura Y, Saeki A, Ueda M, Matsumoto R, Asa-oka H, Clarke JM, Harada Y, Umemoto E, Komatsu N, Okada T, Takayanagi H, Takeda K, Tomura M, Hase K Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine 58, 102913 (2021) 238 Takahashi H, Nomura H, Iriki H, Kubo A, Isami K, Mikami Y, Mukai M, Sasaki T, Yama-gami J, Kudoh J, Ito H, Kamata A, Kurebayashi Y, Yoshida H, Yoshimura A, Sun HW, Suematsu M, O’Shea JJ, Kanno Y, Amagai M. Cholesterol 25-hydroxylase is a meta-bolic switch to constrain T cell-mediated inflammation in the skin. Sci Immunol 6, eabb6444 (2021)

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