RIKEN IMS AnnualReport 2021

95/104

89 123 Lin B, Grinde K, Brody J, Breeze C, Raffield L, Mychaleckyj J, Thornton T, Perry J, Baier L, de Las Fuentes L, Guo X, Heavner B, Hanson R, Hung Y, Qian H, Hsiung C, Hwang S, Irvin M, Jain D, Kelly T, Kobes S, Lange L, Lash J, Li Y, Liu X, Mi X, Musani S, Papanico-laou G, Parsa A, Reiner A, Salimi S, Sheu W, Shuldiner A, Taylor K, Smith A, Smith J, Tin A, Vaidya D, Wallace R, Yamamoto K, Sakaue S, Matsuda K, Kamatani Y, Momozawa Y, Yanek L, Young B, Zhao W, Okada Y, Abecasis G, Psaty B, Arnett D, Boerwinkle E, Cai J, Yii-Der Chen I, Correa A, Cupples L, He J, Kardia S, Kooperberg C, Mathias R, Mitchell B, Nickerson D, Turner S, Vasan R, Rotter J, Levy D, Kramer H, Köttgen A, Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium, TOPMed Kidney Working Group, Rich S, Lin D, Browning S, Franceschini N. Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for preci-sion medicine (TOPMed) consortium. EBioMedicine 63, 103157 (2021) 124 Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Ebi H, Kohmoto T, Imoto I, Kasugai Y, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Okada R, Mikami H, Takezaki T, Suzuki S, Taiki Y, Iwasaki M, Sawada N, Goto A, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka SS, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yu H, Zhong J, Amundadottir LT, Doki Y, Ishii H, Eguchi H, Bogumil D, Haiman CA, Marchand LL, Mori M, Risch H, Setiawan VW, Tsugane S, Wakai K, Yoshida T, Matsuda F, Kubo, Kikuchi S, Matsuo K. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun 11, 3175 (2021) 125 Longley RJ, White MT, Brewster J, Liu ZSJ, Bourke C, Takashima E, Harbers M, Tham WH, Healer J, Chitnis CE, Monteiro W, Lacerda M, Sattabongkot J, Tsuboi T, Mueller I. IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection. Open Forum Infect Dis 8, ofab228 (2021) 126 Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumano-goh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S. Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients. J Exp Med 218, e20211327 (2021) 127 Luginbühl J, Kouno T, Nakano R, Chater T, Sivaraman DM, Kishima M, Roudnicky F, Carninci P, Plessy CG, Shin JW. Decoding Neuronal Diversification by Multiplexed Single-cell RNA-Seq. Stem Cell Reports 16, 810-824 (2021) 128 Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D. TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca 2+/CaMKII/Nrf2 signaling pathway. Cell Death Dis 12, 504 (2021) 129 Lv Z, Yang YX, Li J, Fei Y, Guo H, Sun Z, Lu J, Xu X, Jiang Q, Ikegawa S, Shi D. Molecular Classification of Knee Osteoarthritis. Front Cell Dev Biol 9, 725568 (2021) 130 Mackie GM, Copland A, Takahashi M, Nakanishi Y, Everard I, Kato T, Oda H, Kanaya T, Ohno H, Maslowski KM. Bacterial cancer therapy in autochthonous colorectal cancer affects tumor growth and metabolic landscape. JCI Insight 6, e139900 (2021) 131 Mäkitie RE, Pekkinen M, Morisada N, Kobayashi D, Yonezawa Y, Nishimura G, Ikegawa S, Mäkitie O. A Novel IFITM5 Variant Associated with Phenotype of Osteoporosis with Calvarial Doughnut Lesions: A Case Report. Calcif Tissue Int 109, 626-632 (2021) 132 Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C. Re-capitulating the human segmentation clock with pluripotent stem cells. Nature 580, 124-129 (2021) 133 Matsui H, Shirakawa K, Konishi Y, Hirabayashi S, Sarca AD, Fukuda H, Nomura R, Stanford E, Horisawa Y, Kazuma Y, Matsumoto T, Yamazaki H, Murakawa Y, Battivelli E, Verdin E, Koyanagi Y, Takaori-Kondo A. CAGE-Seq Reveals that HIV-1 Latent Infec-tion Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model. J Virol 95, e02394-20 (2021) 134 Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y, Shiraga K, Sasaki H, Ishida A, Takahashi S, Okada T, Toyooka K, Sharif J, Abe T, Kiyonari H, Tominaga M, Miyawaki A, Amagai M. A unique mode of keratinocyte death requires intracellular acidification. Proc Natl Acad Sci U S A 118, e2020722118 (2021) 135 Matsuyama T, Machida K, Motomura Y, Takagi K, Doutake Y, Tanoue-Hamu A, Kondo K, Mizuno K, Moro K, Inoue H. Long-acting muscarinic antagonist regulates group 2 innate lymphoid cell-dependent airway eosinophilic inflammation. Allergy 76, 2785-2796 (2021) 136 Mei H, Kozuka C, Hayashi R, Kumon M, Koseki H, Inoue A. H2AK119ub1 guides mater-nal inheritance and zygotic deposition of H3K27me3 in mouse embryos. Nat Genet 53, 539-550 (2021) 137 Mi-Ichi F, Ikeda K, Tsugawa H, Deloer S, Yoshida H, Arita M. Stage-specific de novo synthesis of very long chain dihydroceramides confers dormancy in Entamoeba para-sites. mSphere 6, e00174-21 (2021) 138 Miyata J, Yokokura Y, Moro K, Arai H, Fukunaga K, Arita M. 12/15-Lipoxygenase Regu-lates IL-33-induced Eosinophilic Airway Inflammation in Mice. Front Immunol 12, 687192 (2021) 139 Miyatake S, Kato M, Kumamoto T, Hirose T, Koshimizu E, Matsui T, Takeuchi H, Doi H, Hamada K, Nakashima M, Sasaki K, Yamashita A, Takata A, Hamanaka K, Satoh M, Mi-yama T, Sonoda Y, Sasazuki M, Torisu H, Hara T, Sakai Y, Noguchi Y, Miura M, Nishimura Y, Nakamura K, Asai H, Hinokuma N, Miya F, Tsunoda T, Togawa M, Ikeda Y, Kimura N, Amemiya K, Horino A, Fukuoka M, Ikeda H, Merhav G, Ekhilevitch N, Miura M, Mizu-guchi T, Miyake N, Suzuki A, Ohga S, Saitsu H, Takahashi H, Tanaka F, Ogata K, Ohtaka-Maruyama C, Matsumoto N. De novo ATP1A3 variants cause polymicrogyria. Sci Adv 7, eabd2368 (2021) 140 Miyatake S, Kato M, Kumamoto T, Hirose T, Koshimizu E, Matsui T, Takeuchi H, Doi H, Hamada K, Nakashima M, Sasaki K, Yamashita A, Takata A, Hamanaka K, Satoh M, Mi-yama T, Sonoda Y, Sasazuki M, Torisu H, Hara T, Sakai Y, Noguchi Y, Miura M, Nishimura Y, Nakamura K, Asai H, Hinokuma N, Miya F, Tsunoda T, Togawa M, Ikeda Y, Kimura N, Amemiya K, Horino A, Fukuoka M, Ikeda H, Merhav G, Ekhilevitch N, Miura M, Mizu-guchi T, Miyake N, Suzuki A, Ohga S, Saitsu H, Takahashi H, Tanaka F, Ogata K, Ohtaka-Maruyama C, Matsumoto N. De novo ATP1A3 variants cause polymicrogyria. Sci Adv 7, eabd2368 (2021) 141 Miyauchi K, Adachi Y, Tonouchi K, Yajima T, Harada Y, Fukuyama H, Deno S, Iwakura Y, Yoshimura A, Hasegawa H, Yugi K, Fujii SI, Ohara O, Takahashi Y, Kubo M. Influenza virus infection expands the breadth of antibody responses through IL-4 signal in B cells. Nat Commun 12, 3789 (2021) 142 Miyauchi K, Ki S, Ukai M, Suzuki Y, Inoue K, Suda W, Matsui T, Ito Y, Honda K, Koseki H, Ohara O, Tanaka RJ, Okada-Hatakeyama M, Kubo M. Essential Role of STAT3 Signaling in Hair Follicle Homeostasis. Front Immunol 12, 663177 (2021) 143 Miyazawa K, Ito K. Genetic Analysis for Coronary Artery Disease Toward Diverse Popu-lations. Front Genet 12, 766485 (2021) 144 Miyazawa K, Ito K. The Evolving Story in the Genetic Analysis for Heart Failure. Front Cardiovasc Med 8, 646816 (2021) 145 Mizuno S, Yamaguchi R, Hasegawa T, Hayashi S, Fujita M, Zhang F, Koh Y, Lee SY, Yoon SS, Shimizu E, Komura M, Fujimoto A, Nagai M, Kato M, Liang H, Miyano S, Zhang Z, Nakagawa H, Imoto S. Immuno-genomic pan-cancer landscape reveals immune escape mechanisms and immuno-editing histories. Sci Rep 11, 15713 (2021) 146 Mizuno Y, Masuoka H, Kibe M, Kosaka S, Natsuhara K, Hirayama K, Inthavong N, Koun-navong S, Tomita S, Umezaki M. Impact of modernization on urinary concentrations of arsenic, cadmium, lead, and selenium in rural residents of Northern Laos. Am J Hum Biol, e23685 (2021) 147 Mochizuki K, Sharif J, Shirane K, Uranishi K, Bogutz AB, Janssen SM, Suzuki A, Okuda A, Koseki H, Lorincz MC. Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing. Nat Commun 12, 7020 (2021) 148 Mohsen A, Tripathi LP, Mizuguchi K. Deep Learning Prediction of Adverse Drug Reac-tions in Drug Discovery Using Open TG–GATEs and FAERS Databases. Front Drug Discov 1, 768792 (2021) 149 Momiuchi Y, Motomura Y, Suga E, Mizuno H, Kikuta J, Morimoto A, Mochizuki M, Otaki N, Ishii M, Moro K. Group 2 innate lymphoid cells in bone marrow regulate osteoclas-togenesis in a reciprocal manner via RANKL, GM-CSF and IL-13. Int Immunol 33, 573-585 (2021) 150 Morishita S, Kawaji H, Ito M, Hayashizaki Y, Norio K. CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome-negative myeloproliferative neoplasms. Cancer Sci 112, 884-892 (2021) 151 Murakami T, Tanaka N, Takamatsu K, Hakozaki K, Fukumoto K, Masuda T, Mikami S, Shinojima T, Kakimi K, Tsunoda T, Sawada K, Imamura T, Mizuno R, Oya M. Multiplexed single-cell pathology reveals the association of CD8 T-cell heterogeneity with prog-nostic outcomes in renal cell carcinoma. Cancer Immunol Immunother 70, 3001-3013 (2021) 152 Murakami Y, Koyanagi Y, Fukushima M, Yoshimura, Akiyama, Momozawa Y, Ueno S, Terasaki H, Oishi A, Miyata, Ikeda H, Tsujikawa A, Mizobuchi K, Hayashi T, Fujinami K, Tsunoda, Young Park J, Han, Kim M, Seungkyu Lee C, Jin Kim, Kwann Park T, Joo, Joon