RIKEN IMS AnnualReport 2021
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88 88 Jokoji G, Maeda S, Oishi K, Ijuin T, Nakajima M, Tawaratsumida H, Kawamura I, Tominaga H, Taketomi E, Ikegawa S, Taniguchi N. CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. J Biol Chem 297, 100994 (2021) 89 Kato T, Manabe RI, Igarashi H, Kametani F, Hirokawa S, Sekine Y, Fujita N, Saito S, Kawashima Y, Hatano Y, Ando S, Nozaki H, Sugai A, Uemura M, Fukunaga M, Sato T, Koyama A, Saito R, Sugie A, Toyoshima Y, Kawata H, Murayama S, Matsumoto M, Kakita A, Hasegawa M, Ihara M, Kanazawa M, Nishizawa M, Tsuji S, Onodera O. Cande-sartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model. J Clin Invest 131, e140555 (2021) 90 Kato Y, Morikawa T, Kato E, Yoshida K, Imoto Y, Sakashita M, Osawa Y, Takabayashi T, Kubo M, Miura K, Noguchi E, Fujieda S. Involvement of Activation of Mast Cells via IgE Signaling and Epithelial Cell-Derived Cytokines in the Pathogenesis of Pollen Food Al-lergy Syndrome in a Murine Model. J Immunol 206, 2791-2802 (2021) 91 Kawasaki J, Kojima S, Mukai Y, Tomonaga K, Horie M. 100-My history of bornavirus in-fections hidden in vertebrate genomes. Proc Natl Acad Sci U S A 118, e2026235118 (2021) 92 Kenevel R, Cessie SL, Terao C, Slowikowski K, Cui J, Huizinga TW, Costenbader KH, Liao KP, Karlson E, Raychaudhuri, S. Using genetics to prioritize diagnoses for rheumatol-ogy outpatients with inflammatory arthritis. Sci Transl Med 12, eaay1548 (2021) 93 Khaeso K, Komvilaisak P, Chainansamit SO, Nakkam N, Suwannaying K, Kuwatjanakul P, Hikino K, Dornsena A, Kanjanawart S, Laoaroon N, Vannaprasaht S, Taketani T, Tassaneeyakul W. NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine. Drug Metab Pharmacokinet 43, 100436 (2021) 94 Khasnobish A, Takayasu L, Watanabe KI, Nguyen TTT, Arakawa K, Hotta O, Joh K, Na-kano A, Hosomi S, Hattori M, Suda W, Morita H. Dysbiosis in the Salivary Microbiome Associated with IgA Nephropathy-A Japanese Cohort Study. Microbes Environ 36, ME21006 (2021) 95 Kiguchi Y, Nishijima S, Kumar N, Hattori M, Suda W. Long-read metagenomics of mul-tiple displacement amplified DNA of low-biomass human gut phageomes by SACRA pre-processing chimeric reads. DNA Res 28, dsab019 (2021) 96 Kikuchi K, Tatebe T, Sudo Y, Yokoyama M, Kidana K, Chiu YW, Takatori S, Arita M, Hori Y, Tomita T. GPR120 signaling controls amyloid-β degrading activity of matrix metal-loproteinases. J Neurosci 41, 6173-6185 (2021) 97 Kiniwa T, Moro K. Localization and site-specific cell-cell interactions of group 2 innate 98 Kiuchi M, Onodera A, Kokubo K, Ichikawa T, Morimoto Y, Kawakami E, Takayama N, Eto K, Koseki H, Hirahara K, Nakayama T. The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. J Exp Med 218, e20201690 (2021) 99 Kobayashi S, Nagafuchi Y, Okubo M, Sugimori Y, Shirai H, Hatano H, Junko M, Yanaoka H, Takeshima Y, Ota M, Iwasaki Y, Sumitomo S, Okamura T, Yamamoto K, Shoda H, Fujio K. Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis. J Autoimmun 116, 102547 (2021) 100 Kobayashi T, Motomura Y, Moro K. The discovery of group 2 innate lymphoid cells has 101 Kodama K, Takahashi H, Nobuyasu Oiji N, Nakano K, Okumura T, Niimi K, Takahashi E, Guo L, Ikegawa S, Furuichi T. CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage. FEBS Open Bio 10, 1096-1103 (2021) 102 Kojima S, Kamada AJ, Parrish NF. Virus-derived variation in diverse human genomes. 103 Kojima S, Yoshikawa K, Ito J, Nakagawa S, Parrish N, Horie M, Kawano S, Tomonaga K. Virus-like insertions with sequence signatures similar to those of endogenous nonretroviral RNA viruses in the human genome. Proc Natl Acad Sci U S A 118, e2010758118 (2021) 104 Kojima-Kita K, Kuramochi-Miyagawa S, Nakayama M, Miyata H, Jacobsen SE, Ikawa M, Koseki H, Nakano T. MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells. Sci Rep 11, 20472 (2021) 105 Kokaji T, Hatano A, Ito Y, Yugi K, Eto M, Morita K, Ohno S, Fujii M, Hironaka K, Egami R, Terakawa A, Tsuchiya T, Ozaki H, Inoue H, Ueda S, Kubota H, Suzuki Y, Ikeda K, Arita M, Matsumoto M, Nakayama KI, Hirayama A, Soga T, Kuroda S. Transomics analysis lymphoid cells. Int Immunol 33, 251-259 (2021)changed the concept of type 2 immune diseases. Int Immunol 33, 705-709 (2021)PLoS Genet 17, e1009324 (2021)reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity. Sci Signal 13, eaaz1236 (2021) 106 Kong WS, Tsuyama N, Inoue H, Guo Y, Mokuda S, Nobukiyo A, Nakatani N, Yamaide F, Nakano T, Kohno Y, Ikeda K, Nakanishi Y, Ohno H, Arita M, Shimojo N, Kanno M. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s. Sci Rep 11, 13109 (2021) 107 Konishi T, Kusakabe S, Hino A, Inamoto K, Yoshifuji K, Kiridoshi Y, Takeshita K, Sasajima S, Toya T, Igarashi A, Najima Y, Kobayashi T, Doki N, Motooka D, Nakamura S, Suyama M, Suda W, Shiota A, Atarashi K, Hattori M, Honda K, Yokota T, Ohashi K, Shibayama H, Fukushima K, Kakihana K. Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease. Bone Marrow Transplant 56, 1728-1731 (2021) 108 Konishi Y, Ichise H, Watabe T, Oki C, Tsukiji S, Hamazaki Y, Murakawa Y, Takaori-Kondo A, Terai K, Matsuda M. Intravital Imaging Identifies the VEGF-TXA 2 Axis as a Critical Promoter of PGE 2 Secretion from Tumor Cells and Immune Evasion. Cancer Res 81, 4124-4132 (2021) 109 Kordou Z, Skokou M, Tsermpini EE, Chantratita W, Fukunaga K, Mushiroda T, Patrinos GP, Koromina M. Discrepancies and similarities in the genome-informed guidance for psychiatric disorders amongst different regulatory bodies and research consortia us-ing next generation sequencing-based clinical pharmacogenomics data. Pharmacol Res 167, 105538 (2021) 110 Kordou Z, Skokou M, Tsermpinia E, Chantratita W, Fukunaga K, Mushiroda T, Patrinos GP, Koromina M. Discrepancies and similarities in the genome-informed guidance for psychiatric disorders amongst different regulatory bodies and research consortia us-ing next generation sequencing-based clinical pharmacogenomics data. Pharmacol Res 167, 105538 (2021) 111 Koyanagi Y, Akiyama M, Nishiguchi KM, Momozawa Y, Kamatani Y, Takata S, Inai C, Iwasaki Y, Kumano M, Murakami Y, Komori S, Gao D, Kurata K, Hosono K, Ueno S, Hotta Y, Murakami A, Terasaki H, Wada Y, Nakazawa T, Ishibashi T, Ikeda Y, Kubo M, Sonoda KH. Regional differences in genes and variants causing retinitis pigmentosa in Japan. Jpn J Ophthalmol 65, 338-343 (2021) 112 Koyasu S. On the 50th anniversary of the Japanese Society for Immunology. Int Im-munol 33, 639-640 (2021) 113 Kubo M. The role of IL-4 derived from follicular helper T (TFH) cells and type 2 helper T (TH2) cells. Int Immunol 33, 717-722 (2021) 114 Kuehn HS, Chang J, Yamashita M, Niemela JE, Zou C, Okuyama K, Harada J, Stoddard JL, Nunes-Santos CJ, Boast B, Baxter RM, Hsieh EWY, Garofalo M, Fleisher TA, Morio T, Taniuchi I, Dutmer CM, Rosenzweig SD. T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients. J Exp Med 218, e20211118 (2021) 115 Kumar S, Tsunoda T, Sharma A. SPECTRA: a tool for enhanced brain wave signal recog-nition. BMC Bioinformatics 22, 195 (2021) 116 Kumar S, Sharma R, Tsunoda T, Kumarevel T, Sharma A. Forecasting the spread of COVID-19 using LSTM network. BMC Bioinformatics 22, 316 (2021) 117 Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Møller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJ. Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health. Cell Metab 33, 939-956.e8 (2021) 118 Kuwashima Y, Yanagawa M, Abe M, Hiroshima M, Ueda M, Arita M, Sako Y. Compara-tive Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells. Int J Mol Sci 22, 8473 (2021) 119 Kwon AT, Mohri K, Takizawa S, Arakawa T, Takahashi M, Kaczkowski B, Furuno M, Su-zuki H, Tagami S, Mukai H, Arner E. Development of p53 knockout U87MG cell line for unbiased drug delivery testing system using CRISPR-Cas9 and transcriptomic analysis. J Biotechnol 332, 72-82 (2021) 120 Li J, Sun Z, Lv Z, Jiang H, Liu A, Wang M, Tan G, Guo H, Sun H, Wu R, Xu X, Yan W, Jiang Q, Ikegawa S, Shi D. Microtubule Stabilization Enhances the Chondrogenesis of Synovial Mesenchymal Stem Cells. Front Cell Dev Biol 9, 748804 (2021) 121 Li MY, Flora P, Pu H, Bar C, Silva J, Cohen I, Galbo PM Jr, Liu H, Yu X, Jin J, Koseki H, D’Orazio JA, Zheng D, Ezhkova E. UV-induced reduction in Polycomb repression pro-motes epidermal pigmentation. Dev Cell 56, 2547-2561.e8 (2021) 122 Li Y, Honda K. Toward the development of defined microbial therapeutics . Int Immu-nol 33, 761-766 (2021)

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