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87 54 Hartley A, Sanderson E, Granell R, Paternoster L, Zheng J, Smith GD, Southam L, Hatzikotoulas K, Boer CG, van Meurs J, Zeggini E; Genetics of Osteoarthritis Consor-tium, Gregson CL, Tobias JH. Using multivariable Mendelian randomization to esti-mate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index. Int J Epidemiol, dyab251 (2021) 55 Hashimoto K, Jouhilahti EM, Töhönen V, Carninci P, Kere J, Katayama S. Embryonic LTR retrotransposons supply promoter modules to somatic tissues. Genome Res 31, 1983-1993 (2021) 56 Hashimoto M, Saito Y, Nakagawa R, Ogahara I, Takagi S, Takata S, Amitani H, Endo M, Yuki H, Ramilowski J, Severin J, Manabe R, Watanabe T, Ozaki K, Kajita H, FUjiki S, Sato K, Honma T, Uchida N, Fukami T, Okazaki Y, Ohara O, Shultz LD, Yamada M, Taniguchi S, Vyas P, De Hoon M, Momozawa Y, Ishikawa F. Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nat Cancer 2, 340-356 (2021) 57 Helman G, Lajoie BR, Crawford J, Takanohashi A, Walkiewicz M, Dolzhenko E, Gross AM, Gainullin VG, Bent SJ, Jenkinson EM, Ferdinandusse S, Waterham HR, Dorboz I, Bertini E, Miyake N, Wolf N, Abbink TE, Kirwin SM, Tan CM, Hobson GM, Guo L, Ikegawa S, Pizzino A, Schmidt JL, Bernard G, Schiffmann R, van der Knaap MS, Simons C, Taft RJ, Vanderver A. Genome sequencing in persistently unsolved white matter disorders. Ann Clin Transl Neurol 7, 144-152 (2021) 58 Hikichi Y, Motomura Y, Takeuchi O, Moro K. Posttranscriptional regulation of ILC2 ho-meostatic function via tristetraprolin. J Exp Med 218, e20210181 (2021) 59 Hikino K, Abe Y, Sakashita K, Ozeki T, Mushiroda T. Characteristics of adverse drug reactions associated with antiepileptics at a tertiary children’s hospital in Japan: A retrospective observational cohort study. Epilepsy Res 173, 106614 (2021) 60 Hikino K, Abe Y, Sakashita K, Ozeki T, Mushiroda T. Mar Characteristics of adverse drug reactions associated with antiepileptics at a tertiary children’s hospital in Japan: A retrospective observational cohort study. Epilepsy Res 173, 106614 (2021) 61 Hikino K, Koido M, Otomo N, Tomizuka K, Ikegawa S, Matsuda K, Momozawa Y; Bio-bank Japan Project, Mushiroda T, Terao C. Genome-wide association study of colorec-tal polyps identified highly overlapping polygenic architecture with colorectal cancer. J Hum Genet, doi: 10.1038/s10038-021-00980-4 (Epub 2021) 62 Hikino K, Koido M, Tomizuka K, Liu X, Momozawa Y, Morisaki T, Murakami Y, The Bio-bank Japan Project, Mushiroda T, Terao C. Susceptibility loci and polygenic architec-ture highlight population specific and common genetic features in inguinal hernias. EBioMedicine 70, 103532 (2021) 63 Hirata T, Yamamoto K, Ikeda K, Arita M. Functional lipidomics of vascular endothelial cells in response to laminar shear stress. FASEB J 35, e21301 (2021) 64 Hishida A, Nakatochi, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, Kado-matsu Y, Suzuki S, Nishiyama T, Kuriyama N, Watanabe I, Takezaki T, Nishimoto D, Kuriki K, Arisawa K, Katsuura-Kamano S, Mikami H, Kusakabe M, Oze I, Koyanagi Y, Nakamura Y, Kadota A, Shimanoe, Tanaka K, Ikezaki H, Murata M, Kubo, Momozawa Y, Takeuchi, Wakai K. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study. Nagoya J Med Sci 83, 183-194 (2021) 65 Honda S, Sakai R, Inoue E, Majima M, Konda N, Takada H, Kihara M, Yajima N, Yama-moto K, Nanki T, Yamamoto K, Takeuchi T, Harigai M. Association of methotrexate use and lymphoproliferative disorder in patients with rheumatoid arthritis: Results from a Japanese multi-institutional retrospective study. Modern Rheumatol, doi: 10.1080/14397595.2020.1869370 (Epub 2021) 66 Hosoe J, Kawashima-Sonoyama Y, Miya F, Kadowaki H, Suzuki K, Kato T, Matsuzawa F, Aikawa SI, Okada Y, Tsunoda T, Hanaki K, Kanzaki S, Shojima N, Yamauchi T, Kadowaki T. Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR Variants. Diabetes 70, 1874-1884 (2021) 67 Hosoe J, Suzuki K, Miya F, Kato T, Tsunoda T, Okada Y, Horikoshi M, Shojima N, Yamau-chi T, Kadowaki T. Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes. Hum Genome Var 8, 25 (2021) 68 Inez J, Hernández-López P, Heijhuurs S, Bongiovanni L, de Bruin A, Beringer D, Dooremalen S, Shultz L, Ishikawa F, Sebestyen Z, Straetemans T, Kuball J. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. J Leukoc Biol 107, 1069-1079 (2021) 69 Inoue I, Qin XY, Masaki T, Mezaki Y, Matsuura T, Kojima S, Furutani Y. Latency-associ-ated Peptide Degradation Fragments Produced in Stellate Cells and Phagocytosed by Macrophages in Bile Duct-ligated Mouse Liver. J Histochem Cytochem 69, 723-730 (2021) 70 Iriki H, Takahashi H, Wada N, Nomura H, Mukai M, Kamata A, Ito H, Yamagami J, Matsui T, Kurebayashi Y, Mise-Omata S, Nishimasu H, Nureki O, Yoshimura A, Hori S, Amagai M. Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. Proc Natl Acad Sci U S A 118, e2026763118 (2021) 71 Ise W, Kurosaki T. Plasma cell generation during T-cell-dependent immune responses. Int Immunol 33, 797-801 (2021) 72 Ishigaki K. Beyond GWAS: from simple associations to functional insights. 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