Following successful launch of the Genome Platform, the laboratory for 44Integrative Genomics has been evolving toward multi-omics science. In 2021, we built a new lab space for proteomics and lab automation (Figure). This space will house four currently functioning and newly introduced mass spectrometers and several liquid handling robots and will be a foundation to provide another layer of omics technologies to IMS. Indeed, the era of multi-omics is coming and our technologies have provided a comprehensive and detailed viewpoint to many biological projects. For instance, our algorithm for quantitative transcriptome has helped to reveal aging of skeletal stem cells and generation of an inflammatory niche (publication 1). Repertoire analysis using next generation sequencing has unveiled the dynamics of differential regulation on IgA reactivity to commensal bacteria (publication 2). RNA-seq technology has unraveled the molecular mechanisms in aggressive acute myeloid leukemia (publication 3). We believe that multi-layer omics approaches at DNA, RNA, protein, and so on levels, become more and more important for comprehensive understanding of biological systems, thus we will continue developing multi-omics technologies.Figure: New environment for proteomics and research automationLab space on the 2nd floor of the North building has been transformed to house cutting-edge mass spec-trometers and liquid handling robots. The laboratory for Integrative Genomics will provide the latest proteomics technologies and lab automation through this infra-structure.Recent Major PublicationsAmbrosi TH, Marecic O, McArdle A, Sinha R, Gulati GS, Tong X, Wang Y, Steininger HM, Hoover MY, Koepke LS, Murphy MP, Sokol J, Seo EY, Tevlin R, Lopez M, Brewer RE, Mascharak S, Lu L, Ajanaku O, Conley SD, Seita J, Morri M, Neff NF, Sahoo D, Yang F, Weissman IL, Lon-gaker MT, Chan CKF. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature 597, 256-262 (2021).Takeuchi T, Miyauchi E, Kanaya T, Kato T, Nakanishi Y, Watanabe T, Kitami T, Taida T, Sasaki T, Negishi H, Shima-moto S, Matsuyama A, Kimura I, Williams IR, Ohara O, Ohno H. Acetate differentially regulates IgA reactivity to commensal bacteria. Nature 595, 560-564 (2021)Hashimoto M, Saito Y, Nakagawa R, Ogahara I, Takagi S, Takata S, Amitani H, Endo M, Yuki H, Ramilowski JA, Sev-erin J, Manabe R, Watanabe T, Ozaki K, Kaneko A, Kajita H, Fujiki S, Sato K, Honma T, Uchida N, Fukami T, Okazaki Y, Ohara O, Shultz LD, Yamada M, Taniguchi S, Vyas P, de Hoon M, Momozawa Y, Ishikawa F. Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nat Cancer 2, 340-356 (2021)Invited presentationsSeita J. “Basic and application of data-driven medical sciences in RIKEN” Keynote at RIKEN-Kumamoto Uni-versity Joint Symposium on DX in Biomedical Science (Kumamoto, Japan/Online) December 2021Seita J. “Potential of Deep Learning in Acute Medicine” Symposium at the 49th Annual Meeting of the Japanese Association for Acute Medicine (Tokyo, Japan) November 2021Seita J. “Role of hybrid scientist in cancer research” The 80th Annual Meeting of the Japanese Cancer Associa-tion (Yokohama/Kanagawa, Japan) October 2021Seita J. “Can AI make revolution in human genetics?” Symposium at the 66th Annual Meeting of the Japan Society of Human Genetics and the 28th Annual Meet-ing of the Japanese Society for Gene Diagnosis and Therapy – Joint Conference (Yokohama/Kanagawa, Japan) October 2021Seita J. “Human lung molecular atlas by single cell RNA-seq” The 61st Annual Meeting of the Japanese Respira-tory Society (Tokyo, Japan) April 2021Laboratory for Integrative GenomicsTeam Leader: Jun Seita
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