RIKEN IMS AnnualReport 2020

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84 103 Liu X, Kosugi S, Koide R, Kawamura Y, Ito J, Miura H, Matoba N, Matsuzaki M, Fujita M, Kamada AJ, Nakagawa H, Tamiya G, Matsuda K, Murakami Y, Kubo, Momozawa Y, Sato K, Ohashi J, Terao C, Yoshikawa T, Parrish N, Kamatani Y. Endogenization and excision of human herpesvirus 6 in human genomes. PLoS Genet 16, e1008915 (2020) 104 Liu X, Takata S, Ashikawa K, Aoi T, Kosugi S, Terao C, Parrish FN, Matsuda K, Nakagawa H, Kamatani Y, Kubo M, Momozawa Y. Prevalence and spectrum of pathogenic germ-line variants in Japanese patients with early-onset colorectal, breast, and prostate cancer. JCO Precis Oncol 3, 183-191 (2020) 105 Lo C, Borjigin L, Saito S, Fukunaga K, Saitou E, Okazaki K, Mizutani T, Wada S, Takeshi-ma S, Aida Y. BoLA-DRB3 Polymorphism is Associated with Differential Susceptibility to Bovine Leukemia Virus-Induced Lymphoma and Proviral Load. Viruses 12, 352 (2020) 106 Luidy-Imada E, Sanchez DF, Collado-Torres L, Wilks C, Matam T, Dinalankara W, Stupnikov A, Lobo-Pereira F, Yip C, Yasuzawa K, Kondo N, Ito M, Suzuki H, Kasukawa T, Hon C, De Hoon M, Shin JW, Carninci P, Jaffe A, Leek JT, Favorov AV, Franco GR, Langmead B, Marchionni L. Recounting the FANTOM Cage Associated Transcriptome. Genome Res 30, 1073-1081 (2020) 107 Madoka I, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Hishida A, Takeuchi K, Okada R, Kubo Y, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Takezaki T, Nishimoto D, Kuriyama N, Ozaki E, Suzuki S, Watanabe M, Mikami H, Nakamura Y, Uemura H, Katsuura-Kamano S, Kuriki K, Kita Y, Takashima N, Nagino M, Momozawa Y, Kubo, Wakai K. Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study. J Epidemiol (Epub 2020) 108 Masuoka H, Suda W, Tomitsuka E, Shindo C, Takayasu L, Horwood P, Greenhill AR, Hat-tori M, Umezaki M, Hirayama K. The influences of low protein diet on the intestinal microbiota of mice. Sci Rep 10, 17077 (2020) 109 Matoba N, Akiyama M, Ishigaki K, Kanai M, Takahashi A, Momozawa Y, Ikegawa S, Ikeda M, Iwata N, Hirata M, Matsuda K, Murakami Y, Kubo M, Kamatani Y, Okada Y. GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits. Nat Hum Behav 4, 308-316 (2020) 110 Matsumoto T, Kodera S, Shinohara H, Yamaguchi T, Higashikuni Y, Kiyosue A, Ito K, Ando J, Takimoto E, Akazawa H, Morita H, Komuro I. Diagnosing Heart Failure from Chest X-Ray Images Using Deep Learning. Int Heart J 61, 781-786 (2020) 111 Matsunaga H, Ito K, Akiyama M, Takahashi A, Koyama S, Nomura S, Ieki H, Ozaki K, Onouchi Y, Sakaue S, Suna S, Ogishima S, Yamamoto M, Hozawa A, Satoh M, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Tanaka K, Arisawa K, Ikezaki H, Takashima N, Naito M, Wakai K, Tanaka H, Sakata Y, Morita H, Sakata Y, Matsuda K, Murakami Y, Akazawa H, Kubo, Kamatani Y, Komuro I. Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. Circ Genom Precis Med 13, e002670 (2020) 112 Mesin L, Schiepers A, Ersching J, Barbulescu A, Cavazzoni CB, Angelini A, Okada T, Kurosaki T, Victora GD. Restricted Clonality and Limited Germinal Center Reentry Char-acterize Memory B Cell Reactivation by Boosting. Cell 180, 92-106.e11 (2020) 113 Michida H, Imoto H, Shinohara H, Yumoto N, Seki M, Umeda M, Hayashi T, Nikaido I, Kasukawa T, Suzuki Y, Okada-Hatakeyama M. The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression. Cell Rep 31, 107724 (2020) 114 Minamide K, Sato T, Nakanishi Y, Ohno H, Kato T, Asano J, Ohteki T. IRF2 maintains the stemness of colonic stem cells by limiting physiolosical stress from interferon. Sci Rep 10, 14639 (2020) 115 Mintz MA, Felce JH, Chou MY, Mayya V, Xu Y, Shui JW, An J, Li Z, Marson A, Okada T, Ware CF, Kronenbreg M, Dustin ML, Cyster JG. The HVEM-BTLA axis restrains T cell help to germinal center B cells and functions as a cell-extrinsic suppressor in lymphoma-genesis. Immunity 51, 310-323 (2020) 116 Miyajima M. Amino acids: key sources for immunometabolites and immunotransmit- 117 Miyajima Y, Ealey KN, Motomura Y, Mochizuki M, Natsuki T, Yanagita M, Economides AN, Nakayama M, Koseki H, Moro K. Effects of BMP7 produced by group 2 innate lym-phoid cells on adipogenesis. Int Immunol 32, 407-419 (2020)ters. Int Immunol 32, 435-446 (2020) 118 Miyamoto J, Igarashi M, Watanabe K, Karaki S, Mukouyama H, Kishino S, Li X, Ichimu-ra A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I. Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. Nat Commun 10, 4007 (2020) 119 Miyata J, Fukunaga K, Kawashima Y, Ohara O, Arita M. Cysteinyl leukotriene metabo-lism of human eosinophils in allergic disease. Allergol Int 69, 28-34 (2020) 120 Miyata J, Fukunaga K, Kawashima Y, Ohara O, Kawana A, Asano K, Arita M. Dysregu-lated metabolism of polyunsaturated fatty acids in eosinophilic allergy diseases. Prostaglandins Other Lipid Mediat 150, 106477 (2020) 121 Miyauchi E, Kim S, Suda W, Kawasumi M, Satoshi O, Atarashi N, Morita H, Taylor T, Hattori M, Ohno H. Gut microorganisms act together to exacerbate inflammation in spinal cords. Nature 585, 102-106 (2020) 122 Miyazaki R, Saiga H, Kato T, Bakoshi T, Senba R, Shintani A, Suzuki M, Takao K, Sasaki I, Iizuka A, Sugiyama M, Iwami N, Fukuda-O Y, Hemmi H. Tanaka T, Miyake M, Kaisho T, Hoshino K. The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene. Biochem Biophys Res Commu 525, 477-482 (2020) 123 Mizukami K, Iwasaki Y, Kawakami E, Hirata M, Kamatani Y, Matsuda K, Endo M, Sugano K, Yoshida T, Murakami Y, Nakagawa H, Spurdle A, Momozawa Y. Genetic char-acterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes. EBioMedicine 60, 103033 (2020) 124 Mizuno S, Ono K, Mikami Y, Naganuma M, Fukuda T, Minami K, Masaoka T, Terada S, Yoshida T, Saigusa, Hirahara N, Miyata H, Suda W, Hattori M, Kanai T. 5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis. Intest Res (2020) 125 Momozawa Y, Merveille, Battaille G, Wiberg M, Koch J, Willesen J, Proschowsky H, Gouni V, Chetboul V, Tiret L, Fredholm M, Seppälä E, Lohi H, Georges M, Lequarré A. Genome wide association study of 40 clinical measurements in eight dog breeds. Sci Rep 10, 6520 (2020) 126 Momozawa Y, Mizukami. Unique roles of rare variants in the genetics of complex diseases in humans. J Hum Genet 66, 11-23 (2020) 127 Morioka MS, Hideya K, Nishimori-Sueki H, Murata M, Kojima-Ishiyama M, Carninci P, Ito M. Cap Analysis of Gene Expression (CAGE), a quantitative and genome-wide assay of transcription start sites. Methods Mol Biol 2020 2120, 277-301 (2020) 128 Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol 17, 403-416 (2020) 129 Mostafa D, Yanagiya A, Georgiadou, Wu Y, Rutter A, Stylianides T, Suzuki T, Yamamoto T. Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Commun Biol 3, 476 (2020) 130 Mutai H, Wasano K, Momozawa Y, Kamatani Y, Miya F, Masuda S, Morimoto N, Nara K, Takahashi S, Tsunoda T, Homma K, Kubo M, Matsunaga T. Variants encoding a restrict-ed carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans. PLoS Genet 16, e1008643 (2020) 131 Nagayama M, Yano T, Atarashi K, Tanoue T, Sekiya M, Kobayashi Y, Sakamoto H, Miura K, Sunada K, Kawaguchi T, Morita S, Sugita K, Narushima S, Barnich N, Isayama J, Kiridooshi Y, Shiota A, Suda W, Hattori M, Yamamoto H, Honda K. TH1 cell-inducing Escherichia coli strain identified from the small intestinal mucosa of patients with Crohn’s disease. Gut Microbes 12, 1788898 (2020) 132 Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi, Yokoi D, Watanabe, Watanabe, Katsuno M, Izumi, Kanai K, Hattori N, Morita, Taniguchi A, Kano, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Okada Y, Ishihara T, Na-kashima K, Kaji R, Kamatani Y, Ikegawa S, Momozawa Y, Kubo, Ishida N, Minegishi N, Nagasaki M, Sobue G. A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis. Commun Biol 3, 526 (2020) 133 Nakamura R, Ozeki T, Hirayama N, Sekine A, Yamashita T, Mashimo Y, Mizukawa Y, Shiohara T, Watanabe H, Sueki H, Ogawa K, Asada H, Kaniwa N, Tsukagoshi E, Matsu-