Studies on Molecular Cellular Pathology and Control of Liver Diseases
“Clarification of Pathogenesis and Drug Discovery toward Hepatic Diseases” :
Identification of novel targets for drug discovery in liver diseases and high throughput screening of their regulatory compounds for future drug discovery utilizing chemical biology techniques.
- Screening of Novel Drugs: Drug discovery and development of new drugs (non- nucleotide analogues) against hepatitis B virus (HBV) utilizing the next generation life science technologies under financial support from AMED.
- Development of New Diagnosis Method: Development of diagnosis, prevention, and therapy against early stage of liver fibrosis targeting novel liver fibrogenesis marker, TGF-β LAP-DP under collaboration with medical universities and companies.
- Molecular Mechanism of Novel Drugs: Studies on nuclear TG2/crosslinking and inactivation of Sp1/selective apoptosis of MYCN positive liver cancer stem cells by a phase III drug candidate, acyclic retinoid (Peretinoin) and their control by foods.
|2018/04/24||Vitamin A derivative selectively kills liver cancer stem cells|
|2016/03/11||How Acyclic retinoid prevents the recurrence of Liver cancer|
AMED Research Program on Hepatitis
Technique to kill selectively hepatocellular carcinoma cells by synthesized chemicals
Technique to detect tissue fibrogenesis using the antibodies against TGF-β LAP degradation products
Analysis of protein-crosslinking activity in the nucleus