Laboratory for Genome Information Analysis

Research Area

Our mission is to understand the origins and functions of non-coding transcription in human genome, with a focus on long non-coding RNAs and enhancer RNAs. We have been at the forefront of annotating these non-coding RNAs using large-scale in-house transcriptomic datasets (e.g. FANTOM). We also integrate our in-house datasets with public epigenomic and genetic (e.g. GWAS and eQTL) datasets to gain insights into the roles of non-coding RNAs in human diseases. Our team is primarily composed of bioinformatic analysts specialized in transcriptomics, but we are working closely with experimental biologists of other teams to provide bioinformatics support on technology development (e.g. single-cell transcriptomics) as well as other collaborative projects. Our research currently focuses on the following areas:
 

  1. Improving the annotation of non-coding RNAs in human and mouse genome by integration of transcriptomic data in large-scale;
  2. Integrating genetic data with our transcriptome annotations, in particular enhancer RNAs, to gain insights into human diseases;
  3. Functional characterization of non-coding RNAs, as part of the FANTOM6 consortium;

 

Research Topics

2017/08/22 FANTOM5 releases first integrated atlas of microRNA expression in human primary cells
2017/03/02 Improved gene expression atlas shows that many human long non-coding RNAs may actually be functional
2015/07/22 A dictionary of the language of cells
2015/02/13 FANTOM5 project discovers general rules governing how cells change
2014/03/27 FANTOM5 releases atlas of human gene expression
2014/03/10 A new bioinformatics tool to visualize transcriptomes