Laboratory for Immune Cell Systems
Publication list of Laboratory for Immune Cell Systems:
2024
1. Nemoto, S., Kubota, T., Ishikura, T., Nakayama, M., Kobayashi, A., Yazaki, J., Uchida, K., Matsuda, M., Kondo, T., Ohara, O., Koseki, H., Koyasu, S. and Ohno, H. (2024) Characterization of metabolic phenotypes and distinctive genes in mice with low weight gain. FASEB J. 38: e23339. (December 9, 2023, doi: 10.1096/fj.202301565R)
2023
1. Otaki, N., Motomura, Y., Terooatea, T., Kelly, S. T., Mochizuki, M., Takeno, N., Koyasu, S., Tamamitsu, M., Sugihara, F., Kikuta, J., Kitamura, H., Shiraishi, Y., Miyanohara, J., Nagano, Y., Saita, Y., Ogura, T., Asano, K., Minoda, A. and Moro, K. (2023) Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis. Nat. Commun. 14: 8120. (December 14, 2023, doi: 10.1038/s41467-023-43336-6)
2. Takeuchi, T., Kubota, T., Nakanishi, Y., Tsugawa, H., Suda, W., Kwon, A. T.-J., Yazaki, J., Ikeda, K., Nemoto, S., Mochizuki, Y., Kitami, T., Yugi, K., Mizuno, Y., Yamamichi, N., Yamazaki, T., Takemoto, I., Kubota, N., Kadowaki, T., Arner, E., Carninci, P., Ohara, O., Arita, M., Hattori, M., Koyasu, S. and Ohno, H. (2023) Gut microbial carbohydrate metabolism contributes to insulin resistance. Nature 621: 389-395. (August 30, 2023, doi: 110.1038/s41586-023-06466-x)
2022
1. Wagner, M. and Koyasu, S. (2022) Cancer immunosurveillance by ILC2s. Trends Cancer 8: 792-794. (July 20, 2022, doi: 10.1016/j.trecan.2022.06.010)
2. Misawa, T., Wagner, M. and Koyasu, S. (2022) ILC2s and adipose tissue homeostasis: Progress to date and the road ahead. Front. Immunol. 13: 876029. (June 16, 2022, doi: 10.3389/fimmu.2022.876029)
3. Nomura, H., Wada, N., Takahashi, H., Kase, Y., Yamagami, J., Egami, S., Iriki, H., Mukai, M., Kamata, A., Itoh, H., Fujii, H., Ishikura, T., Koseki, H., Watanabe, T., Yamada, T., Ohara, O., Koyasu, S. and Amagai, M. (2022) IgM to IgG class-switching is a necessary step for pemphigus phenotype induction in desmoglein 3-specific B cell receptor knock-in mouse. J. Immunol. 208: 582-593. (January 7, 2022, doi: 10.4049/jimmunol.2100781)
2021
1. Ishihama, H., Ishii, K., Nagai, S., Kakinuma, H., Sasaki, A., Yoshioka, K., Kuramoto, T., Shiono, Y., Funao, H., Isogai, N., Tsuji, T., Okada, Y., Koyasu, S., Toyama, Y., Nakamura, M., Aizawa, M. and Matsumoto, M. (2021) An antibacterial coated polymer prevents biofilm formation and implant-associated infection. Sci. Rep. 11: 3602. (February 11, 2021, doi: 10.1038/s41598-021-82992-w)
2. Sumiyoshi, M., Kotani, Y., Ikuta, Y., Suzue, K., Ozawa, M., Katakai, T., Yamada, T., Abe, T., Bando, K., Koyasu, S., Kanaho, Y., Watanabe, T. and Matsuda, S. (2021) Arf1 and Arf6 synergistically maintain survival of T cells during activation. J. Immunol. 206: 366-375. (December 11, 2020, doi: 10.4049/jimmunol.2000971)
2020
1. Wagner, M. and Koyasu, S. (2020) A 3D Skin melanoma spheroid-based model to assess tumor-immune cell interactions. Bio-protocol 10: e3839. (December 5, 2020, doi: 10.21769/BioProtoc.3839)
2. Nakamura, R., Yoshizawa, A., Moriyasu T., Deloer, S., Senba, M., Kikuchi, M., Koyasu, S., Moro, K. and Hamano, S. (2020) Group 2 innate lymphoid cells exacerbate amebic liver abscess in mice. iScience 23: 101544. (September 25, 2020, doi: 10.1016/j.isci.2020.101544)
3. Wagner, M., Ealey, K. N., Tetsu, H., Kiniwa, T., Motomura, Y., Moro, K. and Koyasu S. (2020) Tumour-derived lactic acid contributes to the paucity of intratumoural ILC2s. Cell Rep. 30: 2743-2757. (February 25, 2020, doi: 10.1016/j.celrep.2020.01.103)
2019
1. Sasaki, T., Moro, K., Kubota, T., Kubota, N., Kato, T., Ohno, H., Nakae, S., Saito, H. and Koyasu, S. (2019) Innate lymphoid cells in the induction of obesity. Cell Rep. 28: 202-217. (July 2, 2019, doi: 10.1016/j.celrep.2019.06.016)
2. Wagner, M. and Koyasu, S. (2019) Cancer immunoediting by innate lymphoid cells. Trends Immunol. 40: 415-430. (review) (April 13, 2019, doi: 10.1016/j.it.2019.03.004)
3. Bald, T., Wagner, M., Gao, Y., Koyasu, S. and Smyth, M. J. (2019) Hide and seek: Plasticity of innate lymphoid cells in cancer. Semin. Immunol. 41: 101273. (review) (April 9, 2019, doi: 10.1016/j.smim.2019.04.001)
2018
1. Kabata, H., Moro, K. and Koyasu, S. (2018) The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms. Immunol. Rev. 286: 37-52. (review) (Oct. 7, 2018, doi: 10.1111/imr.12706)
2. Vivier, E., Artis, D., Colonna, M., Diefenbach, A., Di Santo, J. P., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., Powrie, F. and Spits, H. (2018) Innate lymphoid cells: ten years on. Cell 174: 1054-1066. (review) (Aug. 23, 2018, doi: 10.1016/j.cell.2018.07.017)
3. Koga, S., Hozumi, K., Hirano, K., Yazawa, M., Terooatea, T., Minoda, A., Nagasawa, T., Koyasu, S. and Moro, K. (2018) Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2. J. Exp. Med. 215: 1609-1626. (May 4, 2018, doi: 10.1084/jem.20172310)
4. Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. and Betsuyaku, T. (2018) Clarithromycin expands CD11b+Gr-1+ cells to ameliorate shock and post-influenza pneumonia. PLoS Pathog. 14: e1006955. (April 5, 2018, doi: 10.1371/journal.ppat.1006955)
2017
1. Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., Kawashima, T., Kojima, M., Kubosaki, A., Manabe, R., Murata, M., Nagao-Sato, S., Nakazato, K., Ninomiya, N., Nishiyori-Sueki, H., Noma, S., Saijyo, E., Saka, A., Sakai, M., Simon, C., Suzuki, N., Tagami, M., Watanabe, S., Yoshida, S., Arner, P., Axton, R., Babina, M., Baillie, J. K., Barnett, T., Beckhouse, A., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Carlisle, A., Clevers, H., Davis, C., Detmar, M., Dohi, T., Edge, A., Edinger, M., Ehrlund, A., Ekwall, K., Endoh, M., Enomoto, H., Eslami, A., Faglioni, M., Fairbairn, L., Farach-Carson, M., Faulkner, G., Ferrai, C., Fisher, M., Forrester, L., Fujita, R., Furusawa, J.-I., Geijtenbeek, T., Gingeras, T., Goldowitz, D., Guhl, S., Guler, R., Gustincich, S., Ha, T., Hamaguchi, M., Hara, M., Hasegawa, Y., Herlyn, M., Heutink, P., Hitchens, K., Hume, D., Ikawa, T., Ishizu, Y., Kai, C., Kawamoto, H., Kawamura, Y., Kempfle, J., Kenna, T., Kere, J., Khachigian, L., Kitamura, T., Klein, S., Klinken, P., Knox, A., Kojima, S., Koseki, H., Koyasu, S., Lee, W., Lennartsson, A., Mackay-Sim, A., Mejhert, N., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Morris, K., Motohashi, H., Mummery, C., Nakachi, Y., Nakahara, F., Nakamura, T., Nakamura, Y., Nozaki, T., Ogishima, S., Ohkura, N., Ohno, H., Ohshima, M., Okada, M., Okazaki, Y., Orlando, V., Ovchinnikov, D., Passier, R., Patrikakis, M., Pombo, A., Pradhan-Bhatt, S., Qin, X.-Y., Rehli, M., Rizzu, P., Roy, S., Sajantila, A., Sakaguchi, S., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schmidl, C., Schneider, C., Schulze-Tanzil, G., Schwegmann, A., Sheng, G., Shin, J., Sugiyama, D., Sugiyama, T., Summers, K., Takahashi, N., Takai, J., Tanaka, H., Tatsukawa, H., Tomoiu, A., Toyoda, H., van de Wetering, M., van den Berg, L., Verardo, R., Vijayan, D., Wells, C., Winteringham, L., Wolvetang, E., Yamaguchi, Y., Yamamoto, M., Yanagi-Mizuochi, C., Yoneda, M., Yonekura, Y., Zhang, P., Zucchelli, S., Abugessaisa, I., Arner, E., Harshbarger, J., Kondo, A., Lassmann, T., Lizio, M., Sahin, S., Sengstag, T., Severin, J., Shimoji, H., Suzuki, M., Kawai, J., Suzuki, H., Kondo, N., Itoh, M., Daub, C., Kasukawa, T., Carninci, P., Kawaji, H., Forrest, A. and Hayashizaki, Y. (2017) FANTOM5 CAGE profiles of human and mouse samples. Sci. Data 4: 170112. (August 31, 2017, doi: 10. 1038/sdata.2017.112)
2. Ealey, K. N., Moro, K. and Koyasu, S. (2017) Are ILC2s Jekyll and Hyde in airway inflammation? Immunol. Rev. 278: 207-218. (review) (June 28, 2017, doi: 10.1111/imr.12547)
3. Wagner, M., Moro, K. and Koyasu, S. (2017) Plastic heterogeneity of innate lymphoid cells in cancer. Trends in Cancer 5: 326-335. (review) (May 5, 2017, doi: 10.1016/j.trecan.2017.03.008)
4. Ealey, K. N. and Koyasu, S. (2017) Previews: How many subsets of innate lymphoid cells do we need? Immunity 46: 10-13. (commentary) (January 2017, doi: 10.1016/j.immuni.2016.12.018)
2016
1. Morita, H., Moro, K. and Koyasu S. (2016) Innate lymphoid cells in allergic and non-allergic inflammation. J. Allergy Clin. Immunol. 138: 1253-1264. (review) (November 2016, doi: 10.1016/j.jaci.2016.09.011)
2. Kurebayashi, Y., Baba, Y., Minowa, A., Nadya, N. A., Yoshimura, A., Koyasu, S. and Nagai, S. (2016) TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation. Biochem. Biophys. Res. Commun. 480: 114-119. (September 30, 2016, doi: 10.1016/j.bbrc.2016.09.15)
3. Shiono, Y., Ishii, K. Nagai, S., Kakinuma, H., Sasaki, A., Funao, H., Kuramoto, T., Yoshioka, K., Ishihama, H., Isogai, N., Tskeshima, K., Tsuji, T., Okada, Y., Koyasu, S., Nakamura, M., Toyama, Y., Aizawa, M. and Matsumoto, M. (2016) Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant. Sci. Rep. 6: 32758. (September 12, 2016, doi: 10.1038/srep32758.)
4. Yamazumi, Y., Sasaki, O., Imamura, M., Oda, T., Ohno, Y., Shiozaki-Sato, Y., Nagai, S., Suyama, S., Kamoshita, Y., Funato, K., Yasui, T., Kikutani, H., Yamamoto, K., Dohi, M., Koyasu, S. and Akiyama, T. (2016) The RNA binding protein Mex-3B is required for IL-33 induction in the development of allergic airway inflammation. Cell Rep. 16: 2456-2471. (August 17, 2016, doi: 10.1016/j.celrep.2016.07.062.)
5. Funao, H., Nagai, S., Sasaki, A., Hoshikawa, T., Tsuji, T., Okada, Y., Koyasu, S., Toyama, Y., Nakamura, M., Aizawa, M., Matsumoto, M. and Ishii, K. (2016) A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection. Sci. Rep. 6: 23238. (March 17, 2016, doi: 10.1038/srep23238)
6. Koyasu S. (2016) Introduction: innate lymphoid cells special issue. Int. Immunol. 28: 1-2. (review) (January 2016, doi: 10.1093/intimm/dxv073)
7. Moro, K., Kabata, H., Tanabe, M., Koga, S., Takeno, N., Mochizuki, M., Fukunaga, K., Asano, K., Betsuyaku, T. and Koyasu S. (2016) Interferon and IL-27 antagonize group 2 innate lymphoid cell function and type 2 innate immune responses. Nat. Immunol. 17: 76-86. (November 23, 2015, doi: 10.1038/ni.3309)
8. Seed, T. M., Xiao, S., Manley, N., Nikolich-Zugich, J., Pugh, J., Vandenbrink, M. R. M., Hirabayashi, Y., Yasutomo, K., Iwama, A., Koyasu, S., Shterev, I., Sempowski, G., Macchiarini, F., Nakachi, K., Kunugi, K., Hammer, C. and DeWerd, L. (2016) An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: observations, problems, solutions, and lessons learned. Int. J. Rad. Biol. 92: 59-70. (November 17, 2015, doi: 10.3109/09553002.2015.1106024)
2015
1. Kabata, H., Moro, K., Koyasu S. and Asano K. (2015) Group 2 innate lymphoid cells and asthma. Allergol. Int. 64: 227-234. (review) (July, 2015, doi: 10.1016/j.alit.2015.03.004)
2. Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N. and von Zglinicki, T. (2015) Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians. EBioMedicine 2: 1549-1558. (July 21, 2015, doi: 10.1016/j.ebiom.2015.07.029)
3. Morita, H., Arae, K., Unno, H., Miyauchi, K., Toyama, S., Nambu, A., Oboki, K., Ohno, T., Moromura, K., Matsuda, A., Yamaguchi, S., Narushima, S., Kajiwara, N., Iikura, M., Suto, H., McKenzie, A. N., Takahashi, T., Karasuyama, H., Okumura, K., Azuma, M., Moro, K., Akdis, C., Galli, S. J., Koyasu, S., Kubo, M., Sudo, K., Saito, H., Matsumoto, K. and Nakae, S. (2015) An interleukin-33-mast cell-interleukin 2 axis suppresses papain-induced allergic airway inflammation by promoting the expansion of regulatory T cell numbers. Immunity 43:175-186. (July 21, 2015, doi: 10.1016/j.immuni.2015.06.021)
4. Moro, K., Ealey, K. N., Kabata, H. and Koyasu S. (2015) Methods for isolation and analysis of group 2 innate lymphoid cells in mice. Nat. Protoc. 10: 792-806. (April 30, 2015, doi: 10.1038/nprot.2015.047)
5. Vasanthakumar, A., Moro, K., Xin, A., Liao, Y, Gloury, R., Kawamoto, S., Fagarasan, S., Mielke, L. A., Afshar-Sterle, S., Seth L. Masters, S. L., Nakae, S., Saito, H., Wentworth, J. M., Li, P., Liao, W., Leonard, W. J., Smyth, G. K., Shi, W., Nutt, S. L., Koyasu, S. and Kallies, A. (2015) The transcriptional regulators IRF4 and BATF and interleukin 33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat. Immunol. 16: 276-285. (January 19, 2015, doi: 10.1038/ni.3085.)
6. Koyasu, S. (2015) News and Views: Inflammatory ILC2 cells: disguising themselves as progenitor cells? Nat. Immunol. 16: 133-134. (commentary) (January 16, 2015, doi: 10.1038/ni.3080.)
2014
1. Moro, K. and Koyasu, S. (2014) Microbiome and innate lymphoid cells. Semin. Immunopathol. 37: 27-37. (review) (December 13, 2014, doi: 10.1007/s00281-014-0470-4)
2. Diefenbach, A., Colonna, M. and Koyasu, S. (2014) Development, differentiation, and diversity of innate lymphoid cells. Immunity 41: 354-365. (September 18, 2014, doi: 10.1016/j.immuni.2014.09.005)
3. Yoshioka, K., Ishii, K., Kuramoto, T., Nagai, S., Funao, H., Ishihama, H., Shiono, Y., Sasaki, A., Aizawa, M., Okada, Y., Koyasu, S., Toyama, Y. and Matsumoto, M. (2014) A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. PLoS One 9: e106367. (September 3, 2014, doi: 10.1371/journal.pone.0106367)
4. Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Endo, T. A., Kuroki, Y., Ohara, O., Koyasu, S. and Kubo, M. (2014) Basophil-derived IL-4 controls the function of natural helper cells in lung inflammation.Immunity 40:758-771. (May 15, 2014, doi: 10.1016/j.immuni.2014.04.013.)
5. The FANTOM consortium (Furusawa, J.-I., Koyasu, S., and Moro, K. are included from our laboratory). (2014) A promoter level mammalian expression atlas. Nature 507: 462-470. (March 27, 2014, doi: 10.1038/nature13182)
6. Yasui, F., Kohara, M., Kitabatake, M., Nishiwaki, T., Fujii, H., Tateno, C., Yoneda, M., Morita, K., Matsushima, K., Koyasu, S. and Kai, C. (2014) Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS-associated coronavirus. Virology 454-455: 157-168. (March 4, 2014, doi: 10.1016/j.virol.2014.02.005).
2013
1. Kabata, H., Moro, K., Fukunaga, K., Suzuki, Y., Miyata, J., Masaki, K., Betsuyaku, T., Koyasu, S. and Asano K. (2013) Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Nat. Commun. 4: 2675. (October 25, 2013, doi:10.1038/ncomms3675).
2. Furusawa, J.-I., Moro, K., Motomura, Y., Okamoto, K., Zhu, J., Takayanagi, H., Kubo, M. and Koyasu, S. (2013) Critical role of p38 and GATA3 in natural helper cell function. J. Immunol. 191: 1818-1826. (July 12, 2013, doi: 10.4049/jimmunol.1300379)
3. Nishimura, T., Zhao, X., Gan, H., Koyasu, S. and Remold, H. G. (2013) The prostaglandin E2 receptor EP4 is involved in a positive feedback loop for prostaglandin E2 production in human macrophages infected withMycobacterium tuberculosis. FASEB J. 27: 3827-3836. (June 12, 2013, doi:10.1096/fj.13-228858)
4. Koyasu, S. and Moro, K. (2013) Th2-type innate immune responses mediated by natural helper cells. Ann. N. Y. Acad. Sci. 1283: 43-49. (review) (April 23, 2013, doi: 10.1111/nyas.12106)
5. Hirata, Y., Sugie, A., Matsuda, A., Matsuda, S. and Koyasu, S. (2013) TAK1-JNK axis mediates survival signal through Mcl1 stabilization in activated T cells. J. Immunol. 190: 4621-4626. (April 1, 2013, doi: 10.4049/jimmunol.1202809)
6. Nagai, S., Kurebayashi, Y. and Koyasu, S. (2013) Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation. Ann. N. Y. Acad. Sci. 1280: 30-34. (review) (March 28, 2013, doi: 10.1111/nyas.12059)
7. Kurebayashi, Y., Nagai, S., Ikejiri, A. and Koyasu, S. (2013) Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells 18: 247-265. (review) (February 5, 2013, DOI: 10.1111/gtc.12039)
8. Spits, H., Artis, D., Colonna, M., Diefenbach, A., Di Santo, J. P., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N., Mebius, R. E., Powrie, F. and Vivier, E. (2013) Innate lymphoid cells - a proposal for uniform nomenclature. Nat. Rev. Immunol. 13: 145-149. (commentary) (January 7, 2013, doi: 10.1038/nri3365.)
