Laboratory for Developmental Genetics

koseki  

Team Leader

Haruhiko Koseki M.D., Ph.D.

 

1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045

 

haruhiko.koseki at riken.jp

Research Area

The Developmental Genetics Research Group studies epigenetic regulation of organ development and stem cell functions, mediated by Polycomb group (PcG) proteins and DNA methylation (5mC) mechanisms. We showed that PcG proteins bind unmethylated CpG dinucleotides via the CxxC domain of KDM2B, which is a component of the non-canonical polycomb repressive complex 1 (ncPRC1). This promotes deposition of H3K27me3 by the polycomb repressive complex 2 (PRC2), and subsequent recruitment of the canonical PRC1 (cPRC1)- leading to transcriptional silencing. We aim to uncover the factors that regulate: (1) ncPRC1 recruitment to unmethylated CpGs, and, (2) cPRC1 recruitment downstream of PRC2.

 

News

2023/08/19

Gene-silencing complexes join forces to inactivate X chromosomes

2023/03/14

The secret to preserving stem cell identity over time

2022/05/17

Mouse stem cells for primitive endoderm established

2021/09/22

Harnessing natural killer T cells to stop cancer

2017/08/04

How an embryo stops being an egg

2014/07/18

Gene regulation turned upside down

2014/03/07

Regulating the control genes

2013/11/22

Building blocks help silence genes