Laboratory for Inflammatory Regulation

Recent Major Publications

 

Peer reviewed publications

 

1, Shin, C., Ito, Y., Ichikawa, S., Tokunaga, M., Sataka-Sogawa, K., Tanaka ,T. MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kB and negatively regulates inflammatory responses. Sci. Rep. 7, 46097, 2017.

 

2, Ono, R., Kaisho, T., Tanaka, T. PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm Sci. Rep. 5, 18327, 2015.

 

3, Tanaka, T., Shibazki, A., Ono, R., Kaisho, T. HSP70 mediates degradation of the p65 subunit ofnuclear factor κB to inhibit inflammatory signaling  Sci. Signal. 7(356), ra119, 2014.

 

4, Yamazaki, C., Sugiyama, M., Ohta, T., Hemmi, H., Hamada, E., Sasaki, I., Fukuda, Y., Yano, T., Nobuoka, M., Hirashima, T., Iizuka, A., Sato, K., Tanaka, T., Hoshino, K., Kaisho, T. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J. Immunol., 190, 6071-6082, 2013.

 

5, Sasaki, I., Hoshino, K., Sugiyama, T., Yamazaki, C., Yano, T., Iizuka, A,. Hemmi, H., Tanaka, T., Saito M, Sugiyama, M., Fukuda, Y., Ohta, T., Sato, K., Ainai, A., Suzuki, T., Hasegawa, H., Toyama-Sorimachi, N., Kohara, H., Nagasawa, T., Kaisho, T. Spi-B is critical for plasmacytoid dendritic cell function and development. Blood 120, 4733-4743, 2012.

 

6, Tanaka, T, Yamamoto, Y., Muromoto, R., Ikeda, O., Sekine, Y., Grusby, M., J., Kaisho, T.,  Matsuda, T. PDLIM2 inhibits T Helper 17 cell development and granulomatous inflammation through degradation of STAT3. Sci. Signal. 4(202), ra85, 2011.

 

7, Yamazaki, C., Miyamoto, R., Hoshino, K., Fukuda, Y., Sasaki, I., Saito, M., Ishiguchi, H. Yano, T., Sugiyama, T., Hemmi, H., Tanaka, T., Hamada, E., Hirashima, T., Amakawa, R., Fukuhara, S., Nomura, S., Ito, T. and Kaisho, T. Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. Biochem. Biophys. Res. Commun. 397, 756-761, 2010.

 

8, Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M: Ablation of C/EBPβ alleviates ER stress and pancreatic b cell failure through the GRP78 chaperone in mice. J. Clin. Invest. 120, 115-126, 2010.

 

9, Yan, P., Fu, J., Qu, Z., Li, S., Tanaka, T., Grusby, M.J., and Xiao, G. PDLIM2 suppresses HTLV-I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood, 113, 4370-4380, 2009

 

10, Uematsu, S., Kaisho, T., Tanaka, T., Matsumoto, M., Yamakami, M., Omori, H., Yamamoto, M., Yoshimori, T., Akira, S.: The C/EBPb isoform 34kDa LAP is responsible for NF-IL6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. J. Immunol. 179, 5378-5386, 2007.

 

11, Tanaka, T., Grusby, M.J., Kaisho, T. : PDLIM2 terminates NF-kB activation by intranuclear sequestration and degradation of p65. Nature Immunol. 8, 584-591, 2007.

 

12, Nakahira, M., Tanaka, T., Robson, B.E., Mizgerd, J.P., Grusby, M.J.: Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL. Immunity 26, 163-176, 2007.

 

13, Hoshino. K., Sugiyama, T., Matsumoto, M., Tanaka, T., Saito, M., Hemmi, H., Ohara, O., Akira, S., and Kaisho, T. : IkB kinase-a is critical for interferon-a production induced by Toll-like receptors 7 and 9. Nature 440, 949-953, 2006.

 

14. Tanaka, T., Soriano, M.A. and Grusby, M.J.: SLIM is a nuclear ubiquitin ligase that negatively regulates STAT signaling. : Immunity, 22, 729-736, 2005.

 

15, Wood, N., Whitters, M.J., Jacobson, B.A., Witekm,J., Sypek, J.P., Kasaian, M., Eppihimer, M.J., Unger, M., Tanaka, T., Goldman, S.J., Collins, M., Donaldson, D.D., Grusby, M.J. : Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J. Exp. Med. 197, 703-709, 2003.

 

Reviews

 

1, Kaisho, T., Tanaka, T. : Turning NF-kB and IRFs on and off in DCs. : Trends Immunol., 29, 329-336, 2008

 

2, Wurster, A.L., Tanaka, T., Grusby, M.J. : The biology of Stat4 and Stat6. : Oncogene 19, 2577-2584, 2000