Laboratory for Human Disease Models

Curriculum Vitae

 

Name: Fumihiko Ishikawa, MD, PhD

          Group Director and Chief Scientist, Laboratory for Human Disease Models

          RIKEN Center for Integrative Medical Sciences (IMS)

 

Education

March, 1997  MD  Kyushu University School of Medicine

March, 2003  PhD Kyushu University Graduate School of Medical Sciences

 

Postdoctoral Training

October, 1998-March, 2002 Post-doctoral fellow, Laboratory of Dr. Makio Ogawa, Medical University of South Carolina

 

Academic Appointments

April, 2005-December, 2005   Instructor, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences

January, 2006-March, 2011   Unit leader, Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology (RCAI)

April, 2011-March, 2013 Group Director, Laboratory for Human Disease Models, RIKEN RCAI

April, 2013-present  Group Director, Laboratory for Human Disease Models, RIKEN IMS

April, 2013-present  Chief Scientist, RIKEN

 

Awards and Honors

April, 2009           Young Scientist Award, Ministry of Education, Culture, Sports, Science, Japan

February, 2014    10th JSPS Award, Japan Society for the Promotion of Science

 

Major Interests

1. Understanding reconstitution of human immunity from hematopoietic stem cells
2. Targeting human hematologic malignancies with poor prognosis

 

Selected Publications

1. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Science Transl Med 5:181ra52, 2013.
2. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood 119:2768-2777, 2012.
3. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nature Biotechnol 28:275-280, 2010.
4. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Science Transl Med 2(17):17ra9, 2010.
5. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice. Proc Natl Acad Sci USA 107:13022-13027, 2010.