Laboratory for Transcriptional Regulation

Publication Lists

Wada H, Ohno-Oishi M, Nike S, Muroi S, Taniuchi I (2018) Requirement for intron structure in activating the Cd8a locus. Proc. Natl. Acad. Sci. USA. 115:3440-3445.

 

Tenno M, Kojo S, Lawir D-F, Hess I, Shiroguchi K, Ebihara T, Endo T, Muroi S, Satoh R, Kawamoto H, Boehm T and Taniuchi I. (2018) Cbfb2 controls differentiation of and confers homing capacity to pre-thymic progenitors. J. Exp. Med. 215:595-610.

 

Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R and Taniuchi I. (2017) Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes. Nat.Commun. 8:702

 

Tenno M, Shiroguchi K, Muroi S, Kawakami E, Koseki K, Kryukov K, Imanishi T, Ginhoux F and Taniuchi I (2017) Cbfb2-deficiency preserves Langerhans cell precursors by lack of selective TGFb receptor signaling. J. Exp. Med. 214:2933-2946

 

Shan Q, Zeng Z, Xing S, Li F, Hartwig S, Gullicksrud A, Kurup S, Van Braeckel-Budimir N, Su Y, Martin MD, Verga MS, Taniuchi I, Harty JT, Peng W, Badovinac V and Xue Xue H-H.  (2017) Runx3 guards cytotoxic CD8+ effectors against Tfh deviation in acute viral infection. Nat. Immunol. 18:931-939.

 

Kakugawa K, Kojo S, Tanaka H, Seo W, Endo T, Kitagawa Y, Muroi S, Teno M, Yasmin N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu, T and Taniuchi I. (2017) Essential roles of SATB1 in specifying T lymphocyte subsets. Cell Rep. 19:1176-1188

 

Seo W, Muroi S, Akiyama K and Taniuchi I. (2017) Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages. Sci Rep. 7:41351.

 

Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T and Sakaguchi S. (2017) Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Nat. Immunol. 18:173-183

 

Taniuchi I (2016) Views on helper/cytotoxic lineage choice from a bottom-up approach. Immunol Review. 271:98-113

 

 Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematus T and Krangel MS. (2015) An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.  J.Exp.Med. 212:809-24.

 

Majumder K, Koues O, Chan E, Kyle K, Horowitz J, Yang-Iott K, Bassing C, Taniuchi I, Krangel M, Oltz E. (2015) Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. J.Exp.Med.  212:107-20.

 

Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen D.G, Yamaguchi N, Koseki H, Taniuchi I, Iwama A. (2014) Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development. Nat Commun. 2014 Dec 18;5:5872. 

 

Kobayashi M, Shelly CW, Seo W, Vemula S, Liu Y, Taniuchi I and Yoshimoto M. (2014) Functional B-1 progenitor cells are present in the hematopoietic stem cell deficient embryo and depend on Cbfβ for their development. Proc. Natl. Acad. Sci. USA. 111:12151-6

 

Wang CQ, Krishnan V, Tay LS, Chin DW, Koh CP, Chooi JY, Nah GS, Du L, Jacob B, Yamashita N, Lai SK, Tan TZ, Mori S, Taniuchi I, Tergaonkar V, Ito Y, Osato M. (2014) Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects. Cell Reports. 8:767-82.

 

Boucheron N, Tschismarov R, Goeschl L, Moser MA, Lagger S, Sakaguchi S, Winter M, Lenz F, Vitko D, Breitwieser FP, Müller L, Hassan H, Bennett KL, Colinge J, Schreiner W, Egawa T, Taniuchi I,

Matthias P, Seiser C and Ellmeier W. (2014) CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol. 15:439-48

 

Tanaka H, Naito T, Muroi S, Seo W, Chihara R, Miyamoto C, Kominami R and Taniuchi I. (2013) Epigenetic Thpok silencing limits the time window to choose CD4+ helper-lineage fate in the thymus.

EMBO J. 32: 1183-94. 

 

Muroi S, Tanaka H, Miyamoto C and Taniuchi I. (2013) Fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.  J. Immunol. 190:1397-401

 

Reis B, Rogoz A, Costa-Pinto F, Taniuchi I and Mucida D. (2013) Mutual expression of Runx3 and ThPOK regulates intestinal CD4 T cell immunity. Nat. Immunol. 14:271-80.

 

Mucida D, Husain M.M, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis B, Huang Y, Lambolez F, Docherty M, Attinger A, Shui J.W, Kim G, Lena C, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, *Taniuchi I and *Cheroutre H.  (2013) Transcriptional Reprogramming of Mature CD4 T helper Cells generates distinct MHC class II

restricted Cytotoxic T Lymphocytes. Nat. Immunol. 14: 281-9.*corresponding authors.

 

Seo W, Ikawa T, Kawamoto H, and Taniuchi I. (2012) Runx1/Cbfb is essential for early B lymphocyte development through regulation of Ebf1 expression. J.Exp.Med. 209:1255-62

 

Seo W, Tanaka H, Miyamoto C, Levanon D, Groner Y and Taniuchi I. (2012) Roles of VWRPY-motif-mediated gene repression by Runx proteins during T cell development. Immunol.

Cell Biol. 90:827-30

 

Mukai K, BenBarak MJ, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, and Galli SJ. (2012) Critical role of P1-Runx1 in mouse basophil development. Blood 120, 76-85.

 

Hassan H, Sakaguchi S, Tenno M, Kopf A, Boucheron N, Carpenter A.C, Egawa T, Taniuchi  I and Ellmeier W. (2011)  Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8⁺ T cells. Proc. Natl. Acad. Sci. USA. 108:18330-5.

 

Taniuchi I and Ellmeier W. (2011) Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice. Adv. Immunol. 110:71-110.

 

Tachibana M, Tezuka C, Tenno M, Sugiyama M, Yoshida H and Taniuchi I. (2011) Runx1/Cbfb2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages. J. Immunol. 186:1450-57.

 

Sakaguchi S, Hombauer M, Bilic I Naoe Y, Schebesta A, Taniuchi I and Ellmeier W. (2010) The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes. Nat. Immunol. 11:442-448.

 

Engel I, Hammond K, Sullivan B, He X, Taniuchi I, Kappes D and Kronenberg M. (2010) Co-receptor choice by Vα14 iNKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J.Exp.Med. 207:1015-10.

 

Taniuchi I. (2009) Transcriptional regulation in helper versus cytotoxic-lineage decision. Curr. Opin. Immunol. 21:127-132.

 

Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I and Sakaguchi S. (2009) Indispensable role of Runx1/Cbfβ complexes for in vivo suppressive function of FoxP3⁺ regulatory T cells. Immunity 31:609-620.

 

Bruno L, Mazzarella L, Hoogenkamp M,  Hertweck A, Cobb, B.S, Sauer S, Hadjur S, Leleu M, Naoe Y, Taniuchi I, Telfer J. C,  Bonifer C., Fisher A and Merkenschlager M. (2009) Runx proteins regulate Foxp3 expression. J.Exp.Med. 206: 2329-2337.

 

Setoguchi R, Taniuchi I and Bevan M. J. (2009) ThPOK derepression is required for robust CD8 T cell responses to viral infection. J. Immunol. 183:4467-4474.

 

Collins A, Littman D.R, Taniuchi I. (2009) RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat. Rev. Immunol. 9:106-15.

 

Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Satake-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, and Yasutomo K.

(2008) Notch 2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat. Immunol. 9:1140-47.

 

Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H and Taniuchi I. (2008) Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat. Immunol. 9:1113-21.

 

Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C, Okuda T and Taniuchi I. (2008) Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development. Science 319:816-819.

 

Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, Littman D.R and Taniuchi I. (2007) Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfb binding to the Il4 silencer. J.Exp.Med. 204:1749-1755.

 

Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, Hennighausen L, Bendelac A and Littman D.R. (2005) Genetic Evidence supporting selection of the Va14i NKT cell lineage from double positive thymocyte precursors. Immunity  22: 705-716.

 

Taniuchi I, Ellmeier W and Littman D.R. (2004) The CD4/CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Development. Adv. Immunol. 83: 55-89.

 

Taniuchi I, Osato M, Egawa T, Sunshine M.J, Bae S.-C, Komori T, Ito Y and Littman D.R. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111:621-33.

 

Taniuchi I, Sunshine M.J, Festenstein R and Littman D.R. (2002) Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol. Cell 10: 1083-96.

 

Chi T.H, Wan M, Zhao K, Taniuchi I, Chen L, Littman D.R and Crabtree G.R. (2002). Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 418: 195-9.

 

Zou Y-R, Sunshine M.J, Taniuchi I, Hatam F, Killeen N and Littman D.R. (2001). Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat. Genet. 29: 332-6.

 

Zou Y-R, Kottmann A.H, Kuroda M, Taniuchi I and Littman D.R. (1998). Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393: 595-9.