Laboratory for Cytokine Regulation

Welcome to the

Laboratory for Cytokine Regulation

 

The goals of Laboratory for cytokine regulation are to understand the regulatory mechanisms that control immune cell homeostasis in disease situation, particularly focus on allergy, pathogen infection and chronic inflammation.  Cytokines are information tool secreted from many type of immune cells like macrophages, dendritic cells, T cells and innate immune cells. T cells differentiate into several subsets of Helper T (TH) cells, which play a central role in the effector and regulatory functions during pathogenic situation. Distinct TH subsets, TH1, TH2, TH17, and TFH secrete different set of cytokines, and dysregulation in the balance of these TH cell subsets profoundly alter susceptibility to a number of chronic inflammatory diseases including allergy, asthma, and infectious diseases.  Studies from a number of labs including the Kubo lab, have indicated that innate immune cells, mast cells, basophiles, and innate lymphoid cells may also contribute to the pathogenesis of multiple chronic inflammatory diseases by their expressing inflammatory cytokines. Research in the Kubo lab is focusing on how cytokines influence the balance of helper T cell responses and the innate response during immunological surveillance system.